Pseudomonas Exotoxin A: optimized by evolution for effective killing

Pseudomonas Exotoxin A (PE) is the most toxic virulence factor of the pathogenic bacterium Pseudomonas aeruginosa. This review describes current knowledge about the intoxication pathways of PE. Moreover, PE represents a remarkable example for pathoadaptive evolution, how bacterial molecules have bee...

Descripción completa

Detalles Bibliográficos
Autores principales: Michalska, Marta, Wolf, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584936/
https://www.ncbi.nlm.nih.gov/pubmed/26441897
http://dx.doi.org/10.3389/fmicb.2015.00963
_version_ 1782392096890552320
author Michalska, Marta
Wolf, Philipp
author_facet Michalska, Marta
Wolf, Philipp
author_sort Michalska, Marta
collection PubMed
description Pseudomonas Exotoxin A (PE) is the most toxic virulence factor of the pathogenic bacterium Pseudomonas aeruginosa. This review describes current knowledge about the intoxication pathways of PE. Moreover, PE represents a remarkable example for pathoadaptive evolution, how bacterial molecules have been structurally and functionally optimized under evolutionary pressure to effectively impair and kill their host cells.
format Online
Article
Text
id pubmed-4584936
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-45849362015-10-05 Pseudomonas Exotoxin A: optimized by evolution for effective killing Michalska, Marta Wolf, Philipp Front Microbiol Microbiology Pseudomonas Exotoxin A (PE) is the most toxic virulence factor of the pathogenic bacterium Pseudomonas aeruginosa. This review describes current knowledge about the intoxication pathways of PE. Moreover, PE represents a remarkable example for pathoadaptive evolution, how bacterial molecules have been structurally and functionally optimized under evolutionary pressure to effectively impair and kill their host cells. Frontiers Media S.A. 2015-09-15 /pmc/articles/PMC4584936/ /pubmed/26441897 http://dx.doi.org/10.3389/fmicb.2015.00963 Text en Copyright © 2015 Michalska and Wolf. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Michalska, Marta
Wolf, Philipp
Pseudomonas Exotoxin A: optimized by evolution for effective killing
title Pseudomonas Exotoxin A: optimized by evolution for effective killing
title_full Pseudomonas Exotoxin A: optimized by evolution for effective killing
title_fullStr Pseudomonas Exotoxin A: optimized by evolution for effective killing
title_full_unstemmed Pseudomonas Exotoxin A: optimized by evolution for effective killing
title_short Pseudomonas Exotoxin A: optimized by evolution for effective killing
title_sort pseudomonas exotoxin a: optimized by evolution for effective killing
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584936/
https://www.ncbi.nlm.nih.gov/pubmed/26441897
http://dx.doi.org/10.3389/fmicb.2015.00963
work_keys_str_mv AT michalskamarta pseudomonasexotoxinaoptimizedbyevolutionforeffectivekilling
AT wolfphilipp pseudomonasexotoxinaoptimizedbyevolutionforeffectivekilling

Ejemplares similares