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Golgi fragmentation in Alzheimer's disease

The Golgi apparatus is an essential cellular organelle for post-translational modifications, sorting, and trafficking of membrane and secretory proteins. Proper functionality of the Golgi requires the formation of its unique cisternal-stacking morphology. The Golgi structure is disrupted in a variet...

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Autores principales: Joshi, Gunjan, Bekier, Michael E., Wang, Yanzhuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585163/
https://www.ncbi.nlm.nih.gov/pubmed/26441511
http://dx.doi.org/10.3389/fnins.2015.00340
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author Joshi, Gunjan
Bekier, Michael E.
Wang, Yanzhuang
author_facet Joshi, Gunjan
Bekier, Michael E.
Wang, Yanzhuang
author_sort Joshi, Gunjan
collection PubMed
description The Golgi apparatus is an essential cellular organelle for post-translational modifications, sorting, and trafficking of membrane and secretory proteins. Proper functionality of the Golgi requires the formation of its unique cisternal-stacking morphology. The Golgi structure is disrupted in a variety of neurodegenerative diseases, suggesting a common mechanism and contribution of Golgi defects in neurodegenerative disorders. A recent study on Alzheimer's disease (AD) revealed that phosphorylation of the Golgi stacking protein GRASP65 disrupts its function in Golgi structure formation, resulting in Golgi fragmentation. Inhibiting GRASP65 phosphorylation restores the Golgi morphology from Aβ-induced fragmentation and reduces Aβ production. Perturbing Golgi structure and function in neurons may directly impact trafficking, processing, and sorting of a variety of proteins essential for synaptic and dendritic integrity. Therefore, Golgi defects may ultimately promote the development of AD. In the current review, we focus on the cellular impact of impaired Golgi morphology and its potential relationship to AD disease development.
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spelling pubmed-45851632015-10-05 Golgi fragmentation in Alzheimer's disease Joshi, Gunjan Bekier, Michael E. Wang, Yanzhuang Front Neurosci Psychiatry The Golgi apparatus is an essential cellular organelle for post-translational modifications, sorting, and trafficking of membrane and secretory proteins. Proper functionality of the Golgi requires the formation of its unique cisternal-stacking morphology. The Golgi structure is disrupted in a variety of neurodegenerative diseases, suggesting a common mechanism and contribution of Golgi defects in neurodegenerative disorders. A recent study on Alzheimer's disease (AD) revealed that phosphorylation of the Golgi stacking protein GRASP65 disrupts its function in Golgi structure formation, resulting in Golgi fragmentation. Inhibiting GRASP65 phosphorylation restores the Golgi morphology from Aβ-induced fragmentation and reduces Aβ production. Perturbing Golgi structure and function in neurons may directly impact trafficking, processing, and sorting of a variety of proteins essential for synaptic and dendritic integrity. Therefore, Golgi defects may ultimately promote the development of AD. In the current review, we focus on the cellular impact of impaired Golgi morphology and its potential relationship to AD disease development. Frontiers Media S.A. 2015-09-24 /pmc/articles/PMC4585163/ /pubmed/26441511 http://dx.doi.org/10.3389/fnins.2015.00340 Text en Copyright © 2015 Joshi, Bekier and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Joshi, Gunjan
Bekier, Michael E.
Wang, Yanzhuang
Golgi fragmentation in Alzheimer's disease
title Golgi fragmentation in Alzheimer's disease
title_full Golgi fragmentation in Alzheimer's disease
title_fullStr Golgi fragmentation in Alzheimer's disease
title_full_unstemmed Golgi fragmentation in Alzheimer's disease
title_short Golgi fragmentation in Alzheimer's disease
title_sort golgi fragmentation in alzheimer's disease
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585163/
https://www.ncbi.nlm.nih.gov/pubmed/26441511
http://dx.doi.org/10.3389/fnins.2015.00340
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