Pseudogenes in Human Cancer

Recent advances in the analysis of RNA sequencing data have shown that pseudogenes are highly specific markers of cell identity and can be used as diagnostic and prognostic markers. Furthermore, genetically engineered mouse models have recently provided compelling support for a causal link between a...

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Detalles Bibliográficos
Autores principales: Poliseno, Laura, Marranci, Andrea, Pandolfi, Pier Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585173/
https://www.ncbi.nlm.nih.gov/pubmed/26442270
http://dx.doi.org/10.3389/fmed.2015.00068
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author Poliseno, Laura
Marranci, Andrea
Pandolfi, Pier Paolo
author_facet Poliseno, Laura
Marranci, Andrea
Pandolfi, Pier Paolo
author_sort Poliseno, Laura
collection PubMed
description Recent advances in the analysis of RNA sequencing data have shown that pseudogenes are highly specific markers of cell identity and can be used as diagnostic and prognostic markers. Furthermore, genetically engineered mouse models have recently provided compelling support for a causal link between altered pseudogene expression and cancer. In this review, we discuss the most recent milestones reached in the pseudogene field and the use of pseudogenes as cancer classifiers.
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spelling pubmed-45851732015-10-05 Pseudogenes in Human Cancer Poliseno, Laura Marranci, Andrea Pandolfi, Pier Paolo Front Med (Lausanne) Medicine Recent advances in the analysis of RNA sequencing data have shown that pseudogenes are highly specific markers of cell identity and can be used as diagnostic and prognostic markers. Furthermore, genetically engineered mouse models have recently provided compelling support for a causal link between altered pseudogene expression and cancer. In this review, we discuss the most recent milestones reached in the pseudogene field and the use of pseudogenes as cancer classifiers. Frontiers Media S.A. 2015-09-25 /pmc/articles/PMC4585173/ /pubmed/26442270 http://dx.doi.org/10.3389/fmed.2015.00068 Text en Copyright © 2015 Poliseno, Marranci and Pandolfi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Poliseno, Laura
Marranci, Andrea
Pandolfi, Pier Paolo
Pseudogenes in Human Cancer
title Pseudogenes in Human Cancer
title_full Pseudogenes in Human Cancer
title_fullStr Pseudogenes in Human Cancer
title_full_unstemmed Pseudogenes in Human Cancer
title_short Pseudogenes in Human Cancer
title_sort pseudogenes in human cancer
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585173/
https://www.ncbi.nlm.nih.gov/pubmed/26442270
http://dx.doi.org/10.3389/fmed.2015.00068
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