Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures

Neto2 is a transmembrane protein that interacts with the neuron-specific K(+)-Cl(−) cotransporter (KCC2) in the central nervous system (CNS). Efficient KCC2 transport is essential for setting the neuronal Cl(−) gradient, which is required for fast GABAergic inhibition. Neto2 is required to maintain...

Descripción completa

Detalles Bibliográficos
Autores principales: Mahadevan, Vivek, Dargaei, Zahra, Ivakine, Evgueni A., Hartmann, Anna-Maria, Ng, David, Chevrier, Jonah, Ormond, Jake, Nothwang, Hans Gerd, McInnes, Roderick R., Woodin, Melanie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585209/
https://www.ncbi.nlm.nih.gov/pubmed/26441539
http://dx.doi.org/10.3389/fncel.2015.00368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585209/
https://www.ncbi.nlm.nih.gov/pubmed/26441539
http://dx.doi.org/10.3389/fncel.2015.00368

Ejemplares similares