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Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures
Neto2 is a transmembrane protein that interacts with the neuron-specific K(+)-Cl(−) cotransporter (KCC2) in the central nervous system (CNS). Efficient KCC2 transport is essential for setting the neuronal Cl(−) gradient, which is required for fast GABAergic inhibition. Neto2 is required to maintain...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585209/ https://www.ncbi.nlm.nih.gov/pubmed/26441539 http://dx.doi.org/10.3389/fncel.2015.00368 |