Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC

Mathematical models of biochemical networks form a cornerstone of bacterial systems biology. Inconsistencies between simulation output and experimental data point to gaps in knowledge about the fundamental biology of the organism. One such inconsistency centers on the gene aldA in Escherichia coli:...

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Detalles Bibliográficos
Autores principales: Aziz, Ramy K., Khaw, Valerie L., Monk, Jonathan M., Brunk, Elizabeth, Lewis, Robert, Loh, Suh I., Mishra, Arti, Nagle, Amrita A., Satyanarayana, Chitkala, Dhakshinamoorthy, Saravanakumar, Luche, Michele, Kitchen, Douglas B., Andrews, Kathleen A., Palsson, Bernhard Ø., Charusanti, Pep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585216/
https://www.ncbi.nlm.nih.gov/pubmed/26441892
http://dx.doi.org/10.3389/fmicb.2015.00958

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