Compensatory T-type Ca(2+) channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca(2+) channel KO mice

The preferential degeneration of Substantia nigra dopamine midbrain neurons (SN DA) causes the motor-symptoms of Parkinson’s disease (PD). Voltage-gated L-type calcium channels (LTCCs), especially the Cav1.3-subtype, generate an activity-related oscillatory Ca(2+) burden in SN DA neurons, contributi...

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Detalles Bibliográficos
Autores principales: Poetschke, Christina, Dragicevic, Elena, Duda, Johanna, Benkert, Julia, Dougalis, Antonios, DeZio, Roberta, Snutch, Terrance P., Striessnig, Joerg, Liss, Birgit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585382/
https://www.ncbi.nlm.nih.gov/pubmed/26381090
http://dx.doi.org/10.1038/srep13688

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