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Supraspinal Control of Urine Storage and Micturition in Men—An fMRI Study
Despite the crucial role of the brain in the control of the human lower urinary tract, little is known about the supraspinal mechanisms regulating micturition. To investigate the central regulatory mechanisms activated during micturition initiation and actual micturition, we used an alternating sequ...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585491/ https://www.ncbi.nlm.nih.gov/pubmed/24969474 http://dx.doi.org/10.1093/cercor/bhu140 |
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author | Michels, Lars Blok, Bertil F.M. Gregorini, Flavia Kurz, Michael Schurch, Brigitte Kessler, Thomas M. Kollias, Spyros Mehnert, Ulrich |
author_facet | Michels, Lars Blok, Bertil F.M. Gregorini, Flavia Kurz, Michael Schurch, Brigitte Kessler, Thomas M. Kollias, Spyros Mehnert, Ulrich |
author_sort | Michels, Lars |
collection | PubMed |
description | Despite the crucial role of the brain in the control of the human lower urinary tract, little is known about the supraspinal mechanisms regulating micturition. To investigate the central regulatory mechanisms activated during micturition initiation and actual micturition, we used an alternating sequence of micturition imitation/imagination, micturition initiation, and actual micturition in 22 healthy males undergoing functional magnetic resonance imaging. Subjects able to micturate (voiders) showed the most prominent supraspinal activity during the final phase of micturition initiation whereas actual micturition was associated with significantly less such activity. Initiation of micturition in voiders induced significant activity in the brainstem (periaqueductal gray, pons), insula, thalamus, prefrontal cortex, parietal operculum and cingulate cortex with significant functional connectivity between the forebrain and parietal operculum. Subjects unable to micturate (nonvoiders) showed less robust activation during initiation of micturition, with activity in the forebrain and brainstem particularly lacking. Our findings suggest that micturition is controlled by a specific supraspinal network which is essential for the voluntary initiation of micturition. Once this network triggers the bulbospinal micturition reflex via brainstem centers, micturition continues automatically without further supraspinal input. Unsuccessful micturition is characterized by a failure to activate the periaqueductal gray and pons during initiation. |
format | Online Article Text |
id | pubmed-4585491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-45854912015-09-29 Supraspinal Control of Urine Storage and Micturition in Men—An fMRI Study Michels, Lars Blok, Bertil F.M. Gregorini, Flavia Kurz, Michael Schurch, Brigitte Kessler, Thomas M. Kollias, Spyros Mehnert, Ulrich Cereb Cortex Articles Despite the crucial role of the brain in the control of the human lower urinary tract, little is known about the supraspinal mechanisms regulating micturition. To investigate the central regulatory mechanisms activated during micturition initiation and actual micturition, we used an alternating sequence of micturition imitation/imagination, micturition initiation, and actual micturition in 22 healthy males undergoing functional magnetic resonance imaging. Subjects able to micturate (voiders) showed the most prominent supraspinal activity during the final phase of micturition initiation whereas actual micturition was associated with significantly less such activity. Initiation of micturition in voiders induced significant activity in the brainstem (periaqueductal gray, pons), insula, thalamus, prefrontal cortex, parietal operculum and cingulate cortex with significant functional connectivity between the forebrain and parietal operculum. Subjects unable to micturate (nonvoiders) showed less robust activation during initiation of micturition, with activity in the forebrain and brainstem particularly lacking. Our findings suggest that micturition is controlled by a specific supraspinal network which is essential for the voluntary initiation of micturition. Once this network triggers the bulbospinal micturition reflex via brainstem centers, micturition continues automatically without further supraspinal input. Unsuccessful micturition is characterized by a failure to activate the periaqueductal gray and pons during initiation. Oxford University Press 2015-10 2014-06-26 /pmc/articles/PMC4585491/ /pubmed/24969474 http://dx.doi.org/10.1093/cercor/bhu140 Text en © The Author 2014. Published by Oxford University Press http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Articles Michels, Lars Blok, Bertil F.M. Gregorini, Flavia Kurz, Michael Schurch, Brigitte Kessler, Thomas M. Kollias, Spyros Mehnert, Ulrich Supraspinal Control of Urine Storage and Micturition in Men—An fMRI Study |
title | Supraspinal Control of Urine Storage and Micturition in Men—An fMRI Study |
title_full | Supraspinal Control of Urine Storage and Micturition in Men—An fMRI Study |
title_fullStr | Supraspinal Control of Urine Storage and Micturition in Men—An fMRI Study |
title_full_unstemmed | Supraspinal Control of Urine Storage and Micturition in Men—An fMRI Study |
title_short | Supraspinal Control of Urine Storage and Micturition in Men—An fMRI Study |
title_sort | supraspinal control of urine storage and micturition in men—an fmri study |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585491/ https://www.ncbi.nlm.nih.gov/pubmed/24969474 http://dx.doi.org/10.1093/cercor/bhu140 |
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