Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen

In this study, we used high-throughput computational screening to discover drug-like inhibitors of the host MyD88 protein-protein signaling interaction implicated in the potentially lethal immune response associated with Staphylococcal enterotoxins. We built a protein-protein dimeric docking model o...

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Detalles Bibliográficos
Autores principales: Olson, Mark A., Lee, Michael S., Kissner, Teri L., Alam, Shahabuddin, Waugh, David S., Saikh, Kamal U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585646/
https://www.ncbi.nlm.nih.gov/pubmed/26381092
http://dx.doi.org/10.1038/srep14246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585646/
https://www.ncbi.nlm.nih.gov/pubmed/26381092
http://dx.doi.org/10.1038/srep14246

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