Development of Novel Triazolo-Thiadiazoles from Heterogeneous “Green” Catalysis as Protein Tyrosine Phosphatase 1B Inhibitors

Condensed-bicyclic triazolo-thiadiazoles were synthesized via an efficient “green” catalyst strategy and identified as effective inhibitors of PTP1B in vitro. The lead compound, 6-(2-benzylphenyl)-3-phenyl-[1,2,4]triazolo[3][1,3,4]thiadiazole (BPTT) was most effective against human hepatoma cells, i...

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Detalles Bibliográficos
Autores principales: Baburajeev, C. P., Dhananjaya Mohan, Chakrabhavi, Ananda, Hanumappa, Rangappa, Shobith, Fuchs, Julian E., Jagadish, Swamy, Sivaraman Siveen, Kodappully, Chinnathambi, Arunachalam, Ali Alharbi, Sulaiman, Zayed, M. E., Zhang, Jingwen, Li, Feng, Sethi, Gautam, Girish, Kesturu S., Bender, Andreas, Basappa, Rangappa, Kanchugarakoppal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585680/
https://www.ncbi.nlm.nih.gov/pubmed/26388336
http://dx.doi.org/10.1038/srep14195

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