The energy blockers bromopyruvate and lonidamine lead GL15 glioblastoma cells to death by different p53-dependent routes

The energy metabolism of tumor cells relies on aerobic glycolysis rather than mitochondrial oxidation. This difference between normal and cancer cells provides a biochemical basis for new therapeutic strategies aimed to block the energy power plants of cells. The effects produced by the energy block...

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Detalles Bibliográficos
Autores principales: Davidescu, Magdalena, Macchioni, Lara, Scaramozzino, Gaetano, Cristina Marchetti, Maria, Migliorati, Graziella, Vitale, Rita, Corcelli, Angela, Roberti, Rita, Castigli, Emilia, Corazzi, Lanfranco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585687/
https://www.ncbi.nlm.nih.gov/pubmed/26387611
http://dx.doi.org/10.1038/srep14343

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