Dual E627K and D701N mutations in the PB2 protein of A(H7N9) influenza virus increased its virulence in mammalian models

The ongoing avian H7N9 influenza outbreaks in China have caused significant human fatal cases and the virus is becoming established in poultry. Mutations with potential to increase mammalian adaptation have occurred in the polymerase basic protein 2 (PB2) and other viral genes. Here we found that du...

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Detalles Bibliográficos
Autores principales: Zhu, Wenfei, Li, Long, Yan, Zhigang, Gan, Tanhuan, Li, Lifeng, Chen, Rirong, Chen, Ruidong, Zheng, Zuoyi, Hong, Wenshan, Wang, Jia, Smith, David K., Guan, Yi, Zhu, Huachen, Shu, Yuelong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585756/
https://www.ncbi.nlm.nih.gov/pubmed/26391278
http://dx.doi.org/10.1038/srep14170

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