Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder

Mutations that reduce expression or give rise to a Thr85Ser (T85S) mutation of Ca(2+)-CaM-dependent protein kinase kinase-2 (CaMKK2) have been implicated in behavioural disorders such as anxiety, bipolar and schizophrenia in humans. Here we report that Thr85 is an autophosphorylation site that endow...

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Detalles Bibliográficos
Autores principales: Scott, John W., Park, Elizabeth, Rodriguiz, Ramona M., Oakhill, Jonathan S., Issa, Samah M. A., O’Brien, Matthew T., Dite, Toby A., Langendorf, Christopher G., Wetsel, William C., Means, Anthony R., Kemp, Bruce E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585769/
https://www.ncbi.nlm.nih.gov/pubmed/26395653
http://dx.doi.org/10.1038/srep14436

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