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QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers

Strong evidence exists for a central role of amyloid β-protein (Aβ) oligomers in the pathogenesis of Alzheimer’s disease. We have developed a fast, reliable and robust in vitro assay, termed QIAD, to quantify the effect of any compound on the Aβ aggregate size distribution. Applying QIAD, we studied...

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Detalles Bibliográficos
Autores principales:	Brener, Oleksandr, Dunkelmann, Tina, Gremer, Lothar, van Groen, Thomas, Mirecka, Ewa A., Kadish, Inga, Willuweit, Antje, Kutzsche, Janine, Jürgens, Dagmar, Rudolph, Stephan, Tusche, Markus, Bongen, Patrick, Pietruszka, Jörg, Oesterhelt, Filipp, Langen, Karl-Josef, Demuth, Hans-Ulrich, Janssen, Arnold, Hoyer, Wolfgang, Funke, Susanne A., Nagel-Steger, Luitgard, Willbold, Dieter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585794/ https://www.ncbi.nlm.nih.gov/pubmed/26394756 http://dx.doi.org/10.1038/srep13222

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