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Nanoparticles modulate autophagic effect in a dispersity-dependent manner

Autophagy plays a key role in human health and disease, especially in cancer and neurodegeneration. Many autophagy regulators are developed for therapy. Diverse nanomaterials have been reported to induce autophagy. However, the underlying mechanisms and universal rules remain unclear. Here, for the...

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Detalles Bibliográficos
Autores principales: Huang, Dengtong, Zhou, Hualu, Gao, Jinhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585824/
https://www.ncbi.nlm.nih.gov/pubmed/26394839
http://dx.doi.org/10.1038/srep14361
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author Huang, Dengtong
Zhou, Hualu
Gao, Jinhao
author_facet Huang, Dengtong
Zhou, Hualu
Gao, Jinhao
author_sort Huang, Dengtong
collection PubMed
description Autophagy plays a key role in human health and disease, especially in cancer and neurodegeneration. Many autophagy regulators are developed for therapy. Diverse nanomaterials have been reported to induce autophagy. However, the underlying mechanisms and universal rules remain unclear. Here, for the first time, we show a reliable and general mechanism by which nanoparticles induce autophagy and then successfully modulate autophagy via tuning their dispersity. Various well-designed univariate experiments demonstrate that nanomaterials induce autophagy in a dispersity-dependent manner. Aggregated nanoparticles induce significant autophagic effect in comparison with well-dispersed nanoparticles. As the highly stable nanoparticles may block autophagic degradation in autolysosomes, endocytosis and intracellular accumulation of nanoparticles can be responsible for this interesting phenomenon. Our results suggest dispersity-dependent autophagic effect as a common cellular response to nanoparticles, reveal the relationship between properties of nanoparticles and autophagy, and offer a new alternative way to modulate autophagy.
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spelling pubmed-45858242015-09-29 Nanoparticles modulate autophagic effect in a dispersity-dependent manner Huang, Dengtong Zhou, Hualu Gao, Jinhao Sci Rep Article Autophagy plays a key role in human health and disease, especially in cancer and neurodegeneration. Many autophagy regulators are developed for therapy. Diverse nanomaterials have been reported to induce autophagy. However, the underlying mechanisms and universal rules remain unclear. Here, for the first time, we show a reliable and general mechanism by which nanoparticles induce autophagy and then successfully modulate autophagy via tuning their dispersity. Various well-designed univariate experiments demonstrate that nanomaterials induce autophagy in a dispersity-dependent manner. Aggregated nanoparticles induce significant autophagic effect in comparison with well-dispersed nanoparticles. As the highly stable nanoparticles may block autophagic degradation in autolysosomes, endocytosis and intracellular accumulation of nanoparticles can be responsible for this interesting phenomenon. Our results suggest dispersity-dependent autophagic effect as a common cellular response to nanoparticles, reveal the relationship between properties of nanoparticles and autophagy, and offer a new alternative way to modulate autophagy. Nature Publishing Group 2015-09-23 /pmc/articles/PMC4585824/ /pubmed/26394839 http://dx.doi.org/10.1038/srep14361 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Huang, Dengtong
Zhou, Hualu
Gao, Jinhao
Nanoparticles modulate autophagic effect in a dispersity-dependent manner
title Nanoparticles modulate autophagic effect in a dispersity-dependent manner
title_full Nanoparticles modulate autophagic effect in a dispersity-dependent manner
title_fullStr Nanoparticles modulate autophagic effect in a dispersity-dependent manner
title_full_unstemmed Nanoparticles modulate autophagic effect in a dispersity-dependent manner
title_short Nanoparticles modulate autophagic effect in a dispersity-dependent manner
title_sort nanoparticles modulate autophagic effect in a dispersity-dependent manner
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585824/
https://www.ncbi.nlm.nih.gov/pubmed/26394839
http://dx.doi.org/10.1038/srep14361
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