Cargando…
Nanoparticles modulate autophagic effect in a dispersity-dependent manner
Autophagy plays a key role in human health and disease, especially in cancer and neurodegeneration. Many autophagy regulators are developed for therapy. Diverse nanomaterials have been reported to induce autophagy. However, the underlying mechanisms and universal rules remain unclear. Here, for the...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585824/ https://www.ncbi.nlm.nih.gov/pubmed/26394839 http://dx.doi.org/10.1038/srep14361 |
_version_ | 1782392284969435136 |
---|---|
author | Huang, Dengtong Zhou, Hualu Gao, Jinhao |
author_facet | Huang, Dengtong Zhou, Hualu Gao, Jinhao |
author_sort | Huang, Dengtong |
collection | PubMed |
description | Autophagy plays a key role in human health and disease, especially in cancer and neurodegeneration. Many autophagy regulators are developed for therapy. Diverse nanomaterials have been reported to induce autophagy. However, the underlying mechanisms and universal rules remain unclear. Here, for the first time, we show a reliable and general mechanism by which nanoparticles induce autophagy and then successfully modulate autophagy via tuning their dispersity. Various well-designed univariate experiments demonstrate that nanomaterials induce autophagy in a dispersity-dependent manner. Aggregated nanoparticles induce significant autophagic effect in comparison with well-dispersed nanoparticles. As the highly stable nanoparticles may block autophagic degradation in autolysosomes, endocytosis and intracellular accumulation of nanoparticles can be responsible for this interesting phenomenon. Our results suggest dispersity-dependent autophagic effect as a common cellular response to nanoparticles, reveal the relationship between properties of nanoparticles and autophagy, and offer a new alternative way to modulate autophagy. |
format | Online Article Text |
id | pubmed-4585824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45858242015-09-29 Nanoparticles modulate autophagic effect in a dispersity-dependent manner Huang, Dengtong Zhou, Hualu Gao, Jinhao Sci Rep Article Autophagy plays a key role in human health and disease, especially in cancer and neurodegeneration. Many autophagy regulators are developed for therapy. Diverse nanomaterials have been reported to induce autophagy. However, the underlying mechanisms and universal rules remain unclear. Here, for the first time, we show a reliable and general mechanism by which nanoparticles induce autophagy and then successfully modulate autophagy via tuning their dispersity. Various well-designed univariate experiments demonstrate that nanomaterials induce autophagy in a dispersity-dependent manner. Aggregated nanoparticles induce significant autophagic effect in comparison with well-dispersed nanoparticles. As the highly stable nanoparticles may block autophagic degradation in autolysosomes, endocytosis and intracellular accumulation of nanoparticles can be responsible for this interesting phenomenon. Our results suggest dispersity-dependent autophagic effect as a common cellular response to nanoparticles, reveal the relationship between properties of nanoparticles and autophagy, and offer a new alternative way to modulate autophagy. Nature Publishing Group 2015-09-23 /pmc/articles/PMC4585824/ /pubmed/26394839 http://dx.doi.org/10.1038/srep14361 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Huang, Dengtong Zhou, Hualu Gao, Jinhao Nanoparticles modulate autophagic effect in a dispersity-dependent manner |
title | Nanoparticles modulate autophagic effect in a dispersity-dependent manner |
title_full | Nanoparticles modulate autophagic effect in a dispersity-dependent manner |
title_fullStr | Nanoparticles modulate autophagic effect in a dispersity-dependent manner |
title_full_unstemmed | Nanoparticles modulate autophagic effect in a dispersity-dependent manner |
title_short | Nanoparticles modulate autophagic effect in a dispersity-dependent manner |
title_sort | nanoparticles modulate autophagic effect in a dispersity-dependent manner |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585824/ https://www.ncbi.nlm.nih.gov/pubmed/26394839 http://dx.doi.org/10.1038/srep14361 |
work_keys_str_mv | AT huangdengtong nanoparticlesmodulateautophagiceffectinadispersitydependentmanner AT zhouhualu nanoparticlesmodulateautophagiceffectinadispersitydependentmanner AT gaojinhao nanoparticlesmodulateautophagiceffectinadispersitydependentmanner |