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A novel stearic acid-modified hirudin peptidomimetic with improved pharmacokinetic properties and anticoagulant activity

A novel hirudin isoform 3 mimetic peptide, named peptide S2, has been prepared by introduction of a stearic acid modification. Peptide S2 exhibited superior inhibitory activity to hirulog-1 (Bivariludin) and showed significantly higher anticoagulant potency in vivo. Peptide S2 elevated the thrombin...

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Detalles Bibliográficos
Autores principales:	Liu, Zhuguo, Yu, Zheng, Huang, Yuanyuan, Zhang, Yan, Han, Guozhu, Li, Xian, Dong, Mingxin, Yu, Shuo, Wang, Yu, Hu, Jie, Guo, Huiqin, Cheng, Yuanguo, Lv, Li, Dai, Qiuyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585835/ https://www.ncbi.nlm.nih.gov/pubmed/26400022 http://dx.doi.org/10.1038/srep14349

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