Arrhythmogenic effects of mutated L-type Ca(2+)-channels on an optogenetically paced muscular pump in Caenorhabditis elegans

Cardiac arrhythmias are often associated with mutations in ion channels or other proteins. To enable drug development for distinct arrhythmias, model systems are required that allow implementing patient-specific mutations. We assessed a muscular pump in Caenorhabditis elegans. The pharynx utilizes h...

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Detalles Bibliográficos
Autores principales: Schüler, Christina, Fischer, Elisabeth, Shaltiel, Lior, Steuer Costa, Wagner, Gottschalk, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585839/
https://www.ncbi.nlm.nih.gov/pubmed/26399900
http://dx.doi.org/10.1038/srep14427

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