Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine

Methylene blue, currently in phase 3 clinical trials against Alzheimer Disease, disaggregates the Tau protein of neurofibrillary tangles by oxidizing specific cysteine residues. Here, we investigated if methylene blue can inhibit caspases via the oxidation of their active site cysteine. Methylene bl...

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Detalles Bibliográficos
Autores principales: Pakavathkumar, Prateep, Sharma, Gyanesh, Kaushal, Vikas, Foveau, Bénédicte, LeBlanc, Andrea C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585840/
https://www.ncbi.nlm.nih.gov/pubmed/26400108
http://dx.doi.org/10.1038/srep13730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585840/
https://www.ncbi.nlm.nih.gov/pubmed/26400108
http://dx.doi.org/10.1038/srep13730

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