Small cell lung cancer transformation and T790M mutation: complimentary roles in acquired resistance to kinase inhibitors in lung cancer

Lung cancers often harbour a mutation in the epidermal growth factor receptor (EGFR) gene. Because proliferation and survival of lung cancers with EGFR mutation solely depend on aberrant signalling from the mutated EGFR, these tumours often show dramatic responses to EGFR tyrosine kinase inhibitors...

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Detalles Bibliográficos
Autores principales: Suda, Kenichi, Murakami, Isao, Sakai, Kazuko, Mizuuchi, Hiroshi, Shimizu, Shigeki, Sato, Katsuaki, Tomizawa, Kenji, Tomida, Shuta, Yatabe, Yasushi, Nishio, Kazuto, Mitsudomi, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585860/
https://www.ncbi.nlm.nih.gov/pubmed/26400668
http://dx.doi.org/10.1038/srep14447

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