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Decreased bilateral thalamic gray matter volume in first-episode schizophrenia with prominent hallucinatory symptoms: A volumetric MRI study

Studies comparing gray matter (GM) volume of schizophrenic patients with or without auditory verbal hallucinations (AVHs) to that of normal controls remain controversial. This project aims to investigate changes of GM volumes of drug-naïve schizophrenic patients with and without AVHs. Eighteen first...

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Autores principales: Huang, Peng, Xi, Yibin, Lu, Zhong-Lin, Chen, Yunchun, Li, Xiangrui, Li, Weiguo, Zhu, Xia, Cui, Long-Biao, Tan, Qingrong, Liu, Wenming, Li, Chen, Miao, Danmin, Yin, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585923/
https://www.ncbi.nlm.nih.gov/pubmed/26403064
http://dx.doi.org/10.1038/srep14505
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author Huang, Peng
Xi, Yibin
Lu, Zhong-Lin
Chen, Yunchun
Li, Xiangrui
Li, Weiguo
Zhu, Xia
Cui, Long-Biao
Tan, Qingrong
Liu, Wenming
Li, Chen
Miao, Danmin
Yin, Hong
author_facet Huang, Peng
Xi, Yibin
Lu, Zhong-Lin
Chen, Yunchun
Li, Xiangrui
Li, Weiguo
Zhu, Xia
Cui, Long-Biao
Tan, Qingrong
Liu, Wenming
Li, Chen
Miao, Danmin
Yin, Hong
author_sort Huang, Peng
collection PubMed
description Studies comparing gray matter (GM) volume of schizophrenic patients with or without auditory verbal hallucinations (AVHs) to that of normal controls remain controversial. This project aims to investigate changes of GM volumes of drug-naïve schizophrenic patients with and without AVHs. Eighteen first episode schizophrenic (FES) patients with AVHs, 18 FES patients without AVHs, and 18 healthy controls were scanned using structural MRI. Voxel-based morphometry (VBM) analysis was conducted to investigate changes of GM volume among the three groups. Patients with and without AVHs exhibited reduced GM volumes relative to normal controls in the left superior temporal gyrus, frontal regions, cerebellum and caudate. Further analysis of the GM of subcortical structures found that patients with AVHs had reduced thalamic volume than healthy controls. No significant difference was found between patients with and without AVHs. Significant correlation was found between the total scores of the Positive and Negative Syndrome Scale and bilateral thalamic volume. ROC analysis of thalamic volumes of the patients with AVHs and normal controls showed that the area under the curve was 0.698 (P = 0.043). The decreased thalamic volumes might serve as a biomarker for discriminating FES AVHs patients from normals.
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spelling pubmed-45859232015-09-30 Decreased bilateral thalamic gray matter volume in first-episode schizophrenia with prominent hallucinatory symptoms: A volumetric MRI study Huang, Peng Xi, Yibin Lu, Zhong-Lin Chen, Yunchun Li, Xiangrui Li, Weiguo Zhu, Xia Cui, Long-Biao Tan, Qingrong Liu, Wenming Li, Chen Miao, Danmin Yin, Hong Sci Rep Article Studies comparing gray matter (GM) volume of schizophrenic patients with or without auditory verbal hallucinations (AVHs) to that of normal controls remain controversial. This project aims to investigate changes of GM volumes of drug-naïve schizophrenic patients with and without AVHs. Eighteen first episode schizophrenic (FES) patients with AVHs, 18 FES patients without AVHs, and 18 healthy controls were scanned using structural MRI. Voxel-based morphometry (VBM) analysis was conducted to investigate changes of GM volume among the three groups. Patients with and without AVHs exhibited reduced GM volumes relative to normal controls in the left superior temporal gyrus, frontal regions, cerebellum and caudate. Further analysis of the GM of subcortical structures found that patients with AVHs had reduced thalamic volume than healthy controls. No significant difference was found between patients with and without AVHs. Significant correlation was found between the total scores of the Positive and Negative Syndrome Scale and bilateral thalamic volume. ROC analysis of thalamic volumes of the patients with AVHs and normal controls showed that the area under the curve was 0.698 (P = 0.043). The decreased thalamic volumes might serve as a biomarker for discriminating FES AVHs patients from normals. Nature Publishing Group 2015-09-25 /pmc/articles/PMC4585923/ /pubmed/26403064 http://dx.doi.org/10.1038/srep14505 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Huang, Peng
Xi, Yibin
Lu, Zhong-Lin
Chen, Yunchun
Li, Xiangrui
Li, Weiguo
Zhu, Xia
Cui, Long-Biao
Tan, Qingrong
Liu, Wenming
Li, Chen
Miao, Danmin
Yin, Hong
Decreased bilateral thalamic gray matter volume in first-episode schizophrenia with prominent hallucinatory symptoms: A volumetric MRI study
title Decreased bilateral thalamic gray matter volume in first-episode schizophrenia with prominent hallucinatory symptoms: A volumetric MRI study
title_full Decreased bilateral thalamic gray matter volume in first-episode schizophrenia with prominent hallucinatory symptoms: A volumetric MRI study
title_fullStr Decreased bilateral thalamic gray matter volume in first-episode schizophrenia with prominent hallucinatory symptoms: A volumetric MRI study
title_full_unstemmed Decreased bilateral thalamic gray matter volume in first-episode schizophrenia with prominent hallucinatory symptoms: A volumetric MRI study
title_short Decreased bilateral thalamic gray matter volume in first-episode schizophrenia with prominent hallucinatory symptoms: A volumetric MRI study
title_sort decreased bilateral thalamic gray matter volume in first-episode schizophrenia with prominent hallucinatory symptoms: a volumetric mri study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585923/
https://www.ncbi.nlm.nih.gov/pubmed/26403064
http://dx.doi.org/10.1038/srep14505
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