Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus

The influenza A (H1N1) virus causes seasonal epidemics that result in severe illnesses and deaths almost every year. A deep understanding of the antigenic patterns and evolution of human influenza A (H1N1) virus is extremely important for its effective surveillance and prevention. Through developmen...

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Autores principales: Liu, Mi, Zhao, Xiang, Hua, Sha, Du, Xiangjun, Peng, Yousong, Li, Xiyan, Lan, Yu, Wang, Dayan, Wu, Aiping, Shu, Yuelong, Jiang, Taijiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585932/
https://www.ncbi.nlm.nih.gov/pubmed/26412348
http://dx.doi.org/10.1038/srep14171
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author Liu, Mi
Zhao, Xiang
Hua, Sha
Du, Xiangjun
Peng, Yousong
Li, Xiyan
Lan, Yu
Wang, Dayan
Wu, Aiping
Shu, Yuelong
Jiang, Taijiao
author_facet Liu, Mi
Zhao, Xiang
Hua, Sha
Du, Xiangjun
Peng, Yousong
Li, Xiyan
Lan, Yu
Wang, Dayan
Wu, Aiping
Shu, Yuelong
Jiang, Taijiao
author_sort Liu, Mi
collection PubMed
description The influenza A (H1N1) virus causes seasonal epidemics that result in severe illnesses and deaths almost every year. A deep understanding of the antigenic patterns and evolution of human influenza A (H1N1) virus is extremely important for its effective surveillance and prevention. Through development of antigenicity inference method for human influenza A (H1N1), named PREDAC-H1, we systematically mapped the antigenic patterns and evolution of the human influenza A (H1N1) virus. Eight dominant antigenic clusters have been inferred for seasonal H1N1 viruses since 1977, which demonstrated sequential replacements over time with a similar pattern in Asia, Europe and North America. Among them, six clusters emerged first in Asia. As for China, three of the eight antigenic clusters were detected in South China earlier than in North China, indicating the leading role of South China in H1N1 transmission. The comprehensive view of the antigenic evolution of human influenza A (H1N1) virus can help formulate better strategy for its prevention and control.
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spelling pubmed-45859322015-09-30 Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus Liu, Mi Zhao, Xiang Hua, Sha Du, Xiangjun Peng, Yousong Li, Xiyan Lan, Yu Wang, Dayan Wu, Aiping Shu, Yuelong Jiang, Taijiao Sci Rep Article The influenza A (H1N1) virus causes seasonal epidemics that result in severe illnesses and deaths almost every year. A deep understanding of the antigenic patterns and evolution of human influenza A (H1N1) virus is extremely important for its effective surveillance and prevention. Through development of antigenicity inference method for human influenza A (H1N1), named PREDAC-H1, we systematically mapped the antigenic patterns and evolution of the human influenza A (H1N1) virus. Eight dominant antigenic clusters have been inferred for seasonal H1N1 viruses since 1977, which demonstrated sequential replacements over time with a similar pattern in Asia, Europe and North America. Among them, six clusters emerged first in Asia. As for China, three of the eight antigenic clusters were detected in South China earlier than in North China, indicating the leading role of South China in H1N1 transmission. The comprehensive view of the antigenic evolution of human influenza A (H1N1) virus can help formulate better strategy for its prevention and control. Nature Publishing Group 2015-09-28 /pmc/articles/PMC4585932/ /pubmed/26412348 http://dx.doi.org/10.1038/srep14171 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Liu, Mi
Zhao, Xiang
Hua, Sha
Du, Xiangjun
Peng, Yousong
Li, Xiyan
Lan, Yu
Wang, Dayan
Wu, Aiping
Shu, Yuelong
Jiang, Taijiao
Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus
title Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus
title_full Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus
title_fullStr Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus
title_full_unstemmed Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus
title_short Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus
title_sort antigenic patterns and evolution of the human influenza a (h1n1) virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585932/
https://www.ncbi.nlm.nih.gov/pubmed/26412348
http://dx.doi.org/10.1038/srep14171
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