Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus
The influenza A (H1N1) virus causes seasonal epidemics that result in severe illnesses and deaths almost every year. A deep understanding of the antigenic patterns and evolution of human influenza A (H1N1) virus is extremely important for its effective surveillance and prevention. Through developmen...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585932/ https://www.ncbi.nlm.nih.gov/pubmed/26412348 http://dx.doi.org/10.1038/srep14171 |
_version_ | 1782392309407547392 |
---|---|
author | Liu, Mi Zhao, Xiang Hua, Sha Du, Xiangjun Peng, Yousong Li, Xiyan Lan, Yu Wang, Dayan Wu, Aiping Shu, Yuelong Jiang, Taijiao |
author_facet | Liu, Mi Zhao, Xiang Hua, Sha Du, Xiangjun Peng, Yousong Li, Xiyan Lan, Yu Wang, Dayan Wu, Aiping Shu, Yuelong Jiang, Taijiao |
author_sort | Liu, Mi |
collection | PubMed |
description | The influenza A (H1N1) virus causes seasonal epidemics that result in severe illnesses and deaths almost every year. A deep understanding of the antigenic patterns and evolution of human influenza A (H1N1) virus is extremely important for its effective surveillance and prevention. Through development of antigenicity inference method for human influenza A (H1N1), named PREDAC-H1, we systematically mapped the antigenic patterns and evolution of the human influenza A (H1N1) virus. Eight dominant antigenic clusters have been inferred for seasonal H1N1 viruses since 1977, which demonstrated sequential replacements over time with a similar pattern in Asia, Europe and North America. Among them, six clusters emerged first in Asia. As for China, three of the eight antigenic clusters were detected in South China earlier than in North China, indicating the leading role of South China in H1N1 transmission. The comprehensive view of the antigenic evolution of human influenza A (H1N1) virus can help formulate better strategy for its prevention and control. |
format | Online Article Text |
id | pubmed-4585932 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45859322015-09-30 Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus Liu, Mi Zhao, Xiang Hua, Sha Du, Xiangjun Peng, Yousong Li, Xiyan Lan, Yu Wang, Dayan Wu, Aiping Shu, Yuelong Jiang, Taijiao Sci Rep Article The influenza A (H1N1) virus causes seasonal epidemics that result in severe illnesses and deaths almost every year. A deep understanding of the antigenic patterns and evolution of human influenza A (H1N1) virus is extremely important for its effective surveillance and prevention. Through development of antigenicity inference method for human influenza A (H1N1), named PREDAC-H1, we systematically mapped the antigenic patterns and evolution of the human influenza A (H1N1) virus. Eight dominant antigenic clusters have been inferred for seasonal H1N1 viruses since 1977, which demonstrated sequential replacements over time with a similar pattern in Asia, Europe and North America. Among them, six clusters emerged first in Asia. As for China, three of the eight antigenic clusters were detected in South China earlier than in North China, indicating the leading role of South China in H1N1 transmission. The comprehensive view of the antigenic evolution of human influenza A (H1N1) virus can help formulate better strategy for its prevention and control. Nature Publishing Group 2015-09-28 /pmc/articles/PMC4585932/ /pubmed/26412348 http://dx.doi.org/10.1038/srep14171 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Liu, Mi Zhao, Xiang Hua, Sha Du, Xiangjun Peng, Yousong Li, Xiyan Lan, Yu Wang, Dayan Wu, Aiping Shu, Yuelong Jiang, Taijiao Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus |
title | Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus |
title_full | Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus |
title_fullStr | Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus |
title_full_unstemmed | Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus |
title_short | Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus |
title_sort | antigenic patterns and evolution of the human influenza a (h1n1) virus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585932/ https://www.ncbi.nlm.nih.gov/pubmed/26412348 http://dx.doi.org/10.1038/srep14171 |
work_keys_str_mv | AT liumi antigenicpatternsandevolutionofthehumaninfluenzaah1n1virus AT zhaoxiang antigenicpatternsandevolutionofthehumaninfluenzaah1n1virus AT huasha antigenicpatternsandevolutionofthehumaninfluenzaah1n1virus AT duxiangjun antigenicpatternsandevolutionofthehumaninfluenzaah1n1virus AT pengyousong antigenicpatternsandevolutionofthehumaninfluenzaah1n1virus AT lixiyan antigenicpatternsandevolutionofthehumaninfluenzaah1n1virus AT lanyu antigenicpatternsandevolutionofthehumaninfluenzaah1n1virus AT wangdayan antigenicpatternsandevolutionofthehumaninfluenzaah1n1virus AT wuaiping antigenicpatternsandevolutionofthehumaninfluenzaah1n1virus AT shuyuelong antigenicpatternsandevolutionofthehumaninfluenzaah1n1virus AT jiangtaijiao antigenicpatternsandevolutionofthehumaninfluenzaah1n1virus |