Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension

Liver cirrhosis but also portal vein obstruction cause portal hypertension (PHT) and angiogenesis. This study investigated the differences of angiogenesis in cirrhotic and non-cirrhotic PHT with special emphasis on the canonical (Shh/Gli) and non-canonical (Shh/RhoA) hedgehog pathway. Cirrhotic (bil...

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Detalles Bibliográficos
Autores principales: Uschner, Frank E., Ranabhat, Ganesh, Choi, Steve S., Granzow, Michaela, Klein, Sabine, Schierwagen, Robert, Raskopf, Esther, Gautsch, Sebastian, van der Ven, Peter F. M., Fürst, Dieter O., Strassburg, Christian P., Sauerbruch, Tilman, Mae Diehl, Anna, Trebicka, Jonel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585958/
https://www.ncbi.nlm.nih.gov/pubmed/26412302
http://dx.doi.org/10.1038/srep14573

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