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Structural Mechanism for Regulation of Bcl-2 protein Noxa by phosphorylation

We showed previously that phosphorylation of Noxa, a 54-residue Bcl-2 protein, at serine 13 (Ser13) inhibited its ability to promote apoptosis through interactions with canonical binding partner, Mcl-1. Using EPR spectroscopy, molecular dynamics (MD) simulations and binding assays, we offer evidence...

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Detalles Bibliográficos
Autores principales:	Karim, Christine B., Michel Espinoza-Fonseca, L., James, Zachary M., Hanse, Eric A., Gaynes, Jeffrey S., Thomas, David D., Kelekar, Ameeta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585961/ https://www.ncbi.nlm.nih.gov/pubmed/26411306 http://dx.doi.org/10.1038/srep14557

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