Cargando…

Stochastic epigenetic mutations (DNA methylation) increase exponentially in human aging and correlate with X chromosome inactivation skewing in females

In this study we applied a new analytical strategy to investigate the relations between stochastic epigenetic mutations (SEMs) and aging. We analysed methylation levels through the Infinium HumanMethylation27 and HumanMethylation450 BeadChips in a population of 178 subjects ranging from 3 to 106 yea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gentilini, Davide, Garagnani, Paolo, Pisoni, Serena, Bacalini, Maria Giulia, Calzari, Luciano, Mari, Daniela, Vitale, Giovanni, Franceschi, Claudio, Di Blasio, Anna Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586102/ https://www.ncbi.nlm.nih.gov/pubmed/26342808

Ejemplares similares

Epigenome-wide association study in hepatocellular carcinoma: Identification of stochastic epigenetic mutations through an innovative statistical approach
por: Gentilini, Davide, et al.
Publicado: (2017)

Epigenome Wide Association and Stochastic Epigenetic Mutation Analysis on Cord Blood of Preterm Birth
por: Spada, Elena, et al.
Publicado: (2020)

Accelerated epigenetic aging in Down syndrome
por: Horvath, Steve, et al.
Publicado: (2015)

Heterogeneity of Cellular Senescence: Cell Type-Specific and Senescence Stimulus-Dependent Epigenetic Alterations
por: Kwiatkowska, Katarzyna Malgorzata, et al.
Publicado: (2023)

Epigenetic aging differences between Wichí and Criollos from Argentina: Insights from genomic history and ecology
por: Iannuzzi, Vincenzo, et al.
Publicado: (2023)

Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome
por: Guastafierro, T., et al.
Publicado: (2017)

Age-Related Epigenetic Derangement upon Reprogramming and Differentiation of Cells from the Elderly
por: Ravaioli, Francesco, et al.
Publicado: (2018)

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring
por: Horvath, Steve, et al.
Publicado: (2015)

One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project
por: Gensous, Noémie, et al.
Publicado: (2020)

Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder
por: Baldelli, Luca, et al.
Publicado: (2023)

The Impact of Caloric Restriction on the Epigenetic Signatures of Aging
por: Gensous, Noémie, et al.
Publicado: (2019)

Multifactorial analysis of the stochastic epigenetic variability in cord blood confirmed an impact of common behavioral and environmental factors but not of in vitro conception
por: Gentilini, D., et al.
Publicado: (2018)

Skewed X-chromosome inactivation in patients with esophageal carcinoma
por: Li, Gang, et al.
Publicado: (2013)

Role of epigenetics in the clinical evolution of COVID-19 disease. Epigenome-wide association study identifies markers of severe outcome
por: Calzari, Luciano, et al.
Publicado: (2023)

Acceleration of leukocytes’ epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer
por: Durso, Danielle Fernandes, et al.
Publicado: (2017)

A meta-analysis on age-associated changes in blood DNA methylation: results from an original analysis pipeline for Infinium 450k data
por: Bacalini, Maria Giulia, et al.
Publicado: (2015)

Erratum: A meta-analysis on age-associated changes in blood DNA methylation: results from an original analysis pipeline for Infinium 450k data
por: Bacalini, Maria Giulia, et al.
Publicado: (2016)

A Longitudinal Twin Study of Skewed X Chromosome-Inactivation
por: Wong, Chloe Chung Yi, et al.
Publicado: (2011)

Application of the skew exponential power distribution to ROC curves
por: Attwood, Kristopher, et al.
Publicado: (2022)

BEXCIS: Bayesian methods for estimating the degree of the skewness of X chromosome inactivation
por: Yu, Wen-Yi, et al.
Publicado: (2022)

Gene-Based Methods for Estimating the Degree of the Skewness of X Chromosome Inactivation
por: Li, Meng-Kai, et al.
Publicado: (2022)

Epigenetic up-regulation of ribosome biogenesis and more aggressive phenotype triggered by the lack of the histone demethylase JHDM1B in mammary epithelial cells
por: Galbiati, Alice, et al.
Publicado: (2017)

Exponential families of stochastic processes
por: Küchler, Uwe, et al.
Publicado: (1997)

Down syndrome, accelerated aging and immunosenescence
por: Gensous, Noémie, et al.
Publicado: (2020)

Stochastic epigenetic mutations as possible explanation for phenotypical discordance among twins with congenital hypothyroidism
por: Gentilini, D., et al.
Publicado: (2022)

Skewed X-chromosomal inactivation impacts T regulatory cell function in systemic sclerosis
por: Broen, JCA, et al.
Publicado: (2010)

A statistical measure for the skewness of X chromosome inactivation based on family trios
por: Xu, Si-Qi, et al.
Publicado: (2018)

Skewed Inactivation of X Chromosome: A Cause of Hemophilia Manifestation in Carrier Females
por: Shoukat, Hafiz Muhammad Hassan, et al.
Publicado: (2020)

The epigenetic landscape of age-related diseases: the geroscience perspective
por: Gensous, Noémie, et al.
Publicado: (2017)

Identification of a DNA methylation signature in blood cells from persons with Down Syndrome
por: Bacalini, Maria Giulia, et al.
Publicado: (2014)

Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases
por: Chabchoub, Ghazi, et al.
Publicado: (2009)

A statistical measure for the skewness of X chromosome inactivation based on case-control design
por: Wang, Peng, et al.
Publicado: (2019)

Skewed X-Chromosome Inactivation in a Korean Girl with Severe Mucopolysaccharidosis Type II
por: Kim, Hwa Young, et al.
Publicado: (2022)

Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans
por: Roberts, Amy L, et al.
Publicado: (2022)

Epigenetic Variability across Human Populations: A Focus on DNA Methylation Profiles of the KRTCAP3, MAD1L1 and BRSK2 Genes
por: Giuliani, Cristina, et al.
Publicado: (2016)

Familial Skewed X Chromosome Inactivation in Adrenoleukodystrophy Manifesting Heterozygotes from a Chinese Pedigree
por: Wang, Zhihong, et al.
Publicado: (2013)

Nance–Horan syndrome pedigree due to a novel microdeletion and skewed X chromosome inactivation
por: Huang, Yazhou, et al.
Publicado: (2022)

Accelerated bio‐cognitive aging in Down syndrome: State of the art and possible deceleration strategies
por: Franceschi, Claudio, et al.
Publicado: (2019)

Detection of skewed X-chromosome inactivation in Fragile X syndrome and X chromosome aneuploidy using quantitative melt analysis
por: Godler, David E., et al.
Publicado: (2015)

Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications
por: Togliatto, Gabriele, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_lgomuum7mgp7beb767nf1ufdr7