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Experimental Models of Microvascular Immunopathology: The Example of Cerebral Malaria

Human cerebral malaria is a severe and often lethal complication of Plasmodium falciparum infection. Complex host and parasite interactions should the precise mechanisms involved in the onset of this neuropathology. Adhesion of parasitised red blood cells and host cells to endothelial cells lead to...

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Autores principales: El-Assaad, Fatima, Combes, Valery, Grau, Georges ER
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586166/
https://www.ncbi.nlm.nih.gov/pubmed/26430675
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author El-Assaad, Fatima
Combes, Valery
Grau, Georges ER
author_facet El-Assaad, Fatima
Combes, Valery
Grau, Georges ER
author_sort El-Assaad, Fatima
collection PubMed
description Human cerebral malaria is a severe and often lethal complication of Plasmodium falciparum infection. Complex host and parasite interactions should the precise mechanisms involved in the onset of this neuropathology. Adhesion of parasitised red blood cells and host cells to endothelial cells lead to profound endothelial alterations that trigger immunopathological changes, varying degrees of brain oedema and can compromise cerebral blood flow, cause cranial nerve dysfunction and hypoxia. Study of the cerebral pathology in human patients is limited to clinical and genetic field studies in endemic areas, thus cerebral malaria (CM) research relies heavily on experimental models. The availability of malaria models allows study from the inoculation of Plasmodium to the onset of disease and permit invasive experiments. Here, we discuss some aspects of our current understanding of CM, the experimental models available and some important recent findings extrapolated from these models.
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spelling pubmed-45861662015-09-29 Experimental Models of Microvascular Immunopathology: The Example of Cerebral Malaria El-Assaad, Fatima Combes, Valery Grau, Georges ER J Neuroinfect Dis Article Human cerebral malaria is a severe and often lethal complication of Plasmodium falciparum infection. Complex host and parasite interactions should the precise mechanisms involved in the onset of this neuropathology. Adhesion of parasitised red blood cells and host cells to endothelial cells lead to profound endothelial alterations that trigger immunopathological changes, varying degrees of brain oedema and can compromise cerebral blood flow, cause cranial nerve dysfunction and hypoxia. Study of the cerebral pathology in human patients is limited to clinical and genetic field studies in endemic areas, thus cerebral malaria (CM) research relies heavily on experimental models. The availability of malaria models allows study from the inoculation of Plasmodium to the onset of disease and permit invasive experiments. Here, we discuss some aspects of our current understanding of CM, the experimental models available and some important recent findings extrapolated from these models. 2014-01-06 2014-02 /pmc/articles/PMC4586166/ /pubmed/26430675 Text en http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
El-Assaad, Fatima
Combes, Valery
Grau, Georges ER
Experimental Models of Microvascular Immunopathology: The Example of Cerebral Malaria
title Experimental Models of Microvascular Immunopathology: The Example of Cerebral Malaria
title_full Experimental Models of Microvascular Immunopathology: The Example of Cerebral Malaria
title_fullStr Experimental Models of Microvascular Immunopathology: The Example of Cerebral Malaria
title_full_unstemmed Experimental Models of Microvascular Immunopathology: The Example of Cerebral Malaria
title_short Experimental Models of Microvascular Immunopathology: The Example of Cerebral Malaria
title_sort experimental models of microvascular immunopathology: the example of cerebral malaria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586166/
https://www.ncbi.nlm.nih.gov/pubmed/26430675
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