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Regional Intraosseous Administration of Prophylactic Antibiotics is More Effective Than Systemic Administration in a Mouse Model of TKA

BACKGROUND: In human TKA studies, intraosseous regional administration (IORA) of prophylactic antibiotics achieves local tissue antibiotic concentrations 10 times greater than systemic administration. However, it is unclear if such high concentrations provide more effective prophylaxis. QUESTIONS/PU...

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Detalles Bibliográficos
Autores principales:	Young, Simon W., Roberts, Tim, Johnson, Sarah, Dalton, James P., Coleman, Brendan, Wiles, Siouxsie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2015
Materias:	Basic Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586203/ https://www.ncbi.nlm.nih.gov/pubmed/26224291 http://dx.doi.org/10.1007/s11999-015-4464-x

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