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fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents

High-risk behavior in adolescents is associated with injury, mental health problems, and poor outcomes in later life. Improved understanding of the neurobiology of high-risk behavior and impulsivity shows promise for informing clinical treatment and prevention as well as policy to better address hig...

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Autores principales: Brown, Matthew R. G., Benoit, James R. A., Juhás, Michal, Dametto, Ericson, Tse, Tiffanie T., MacKay, Marnie, Sen, Bhaskar, Carroll, Alan M., Hodlevskyy, Oleksandr, Silverstone, Peter H., Dolcos, Florin, Dursun, Serdar M., Greenshaw, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586270/
https://www.ncbi.nlm.nih.gov/pubmed/26483645
http://dx.doi.org/10.3389/fnsys.2015.00124
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author Brown, Matthew R. G.
Benoit, James R. A.
Juhás, Michal
Dametto, Ericson
Tse, Tiffanie T.
MacKay, Marnie
Sen, Bhaskar
Carroll, Alan M.
Hodlevskyy, Oleksandr
Silverstone, Peter H.
Dolcos, Florin
Dursun, Serdar M.
Greenshaw, Andrew J.
author_facet Brown, Matthew R. G.
Benoit, James R. A.
Juhás, Michal
Dametto, Ericson
Tse, Tiffanie T.
MacKay, Marnie
Sen, Bhaskar
Carroll, Alan M.
Hodlevskyy, Oleksandr
Silverstone, Peter H.
Dolcos, Florin
Dursun, Serdar M.
Greenshaw, Andrew J.
author_sort Brown, Matthew R. G.
collection PubMed
description High-risk behavior in adolescents is associated with injury, mental health problems, and poor outcomes in later life. Improved understanding of the neurobiology of high-risk behavior and impulsivity shows promise for informing clinical treatment and prevention as well as policy to better address high-risk behavior. We recruited 21 adolescents (age 14–17) with a wide range of high-risk behavior tendencies, including medically high-risk participants recruited from psychiatric clinics. Risk tendencies were assessed using the Adolescent Risk Behavior Screen (ARBS). ARBS risk scores correlated highly (0.78) with impulsivity scores from the Barratt Impulsivity scale (BIS). Participants underwent 4.7 Tesla functional magnetic resonance imaging (fMRI) while performing an emotional Go/NoGo task. This task presented an aversive or neutral distractor image simultaneously with each Go or NoGo stimulus. Risk behavior and impulsivity tendencies exhibited similar but not identical associations with fMRI activation patterns in prefrontal brain regions. We interpret these results as reflecting differences in response inhibition, emotional stimulus processing, and emotion regulation in relation to participant risk behavior tendencies and impulsivity levels. The results are consistent with high impulsivity playing an important role in determining high risk tendencies in this sample containing clinically high-risk adolescents.
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spelling pubmed-45862702015-10-19 fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents Brown, Matthew R. G. Benoit, James R. A. Juhás, Michal Dametto, Ericson Tse, Tiffanie T. MacKay, Marnie Sen, Bhaskar Carroll, Alan M. Hodlevskyy, Oleksandr Silverstone, Peter H. Dolcos, Florin Dursun, Serdar M. Greenshaw, Andrew J. Front Syst Neurosci Neuroscience High-risk behavior in adolescents is associated with injury, mental health problems, and poor outcomes in later life. Improved understanding of the neurobiology of high-risk behavior and impulsivity shows promise for informing clinical treatment and prevention as well as policy to better address high-risk behavior. We recruited 21 adolescents (age 14–17) with a wide range of high-risk behavior tendencies, including medically high-risk participants recruited from psychiatric clinics. Risk tendencies were assessed using the Adolescent Risk Behavior Screen (ARBS). ARBS risk scores correlated highly (0.78) with impulsivity scores from the Barratt Impulsivity scale (BIS). Participants underwent 4.7 Tesla functional magnetic resonance imaging (fMRI) while performing an emotional Go/NoGo task. This task presented an aversive or neutral distractor image simultaneously with each Go or NoGo stimulus. Risk behavior and impulsivity tendencies exhibited similar but not identical associations with fMRI activation patterns in prefrontal brain regions. We interpret these results as reflecting differences in response inhibition, emotional stimulus processing, and emotion regulation in relation to participant risk behavior tendencies and impulsivity levels. The results are consistent with high impulsivity playing an important role in determining high risk tendencies in this sample containing clinically high-risk adolescents. Frontiers Media S.A. 2015-09-29 /pmc/articles/PMC4586270/ /pubmed/26483645 http://dx.doi.org/10.3389/fnsys.2015.00124 Text en Copyright © 2015 Brown, Benoit, Juhás, Dametto, Tse, MacKay, Sen, Carroll, Hodlevskyy, Silverstone, Dolcos, Dursun and Greenshaw. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Brown, Matthew R. G.
Benoit, James R. A.
Juhás, Michal
Dametto, Ericson
Tse, Tiffanie T.
MacKay, Marnie
Sen, Bhaskar
Carroll, Alan M.
Hodlevskyy, Oleksandr
Silverstone, Peter H.
Dolcos, Florin
Dursun, Serdar M.
Greenshaw, Andrew J.
fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents
title fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents
title_full fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents
title_fullStr fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents
title_full_unstemmed fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents
title_short fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents
title_sort fmri investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586270/
https://www.ncbi.nlm.nih.gov/pubmed/26483645
http://dx.doi.org/10.3389/fnsys.2015.00124
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