Sir2 phosphorylation through cAMP-PKA and CK2 signaling inhibits the lifespan extension activity of Sir2 in yeast

Silent information regulator 2 (Sir2), an NAD(+)-dependent protein deacetylase, has been proposed to be a longevity factor that plays important roles in dietary restriction (DR)-mediated lifespan extension. In this study, we show that the Sir2's role for DR-mediated lifespan extension depends o...

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Detalles Bibliográficos
Autores principales: Kang, Woo Kyu, Kim, Yeong Hyeock, Kang, Hyun Ah, Kwon, Ki-Sun, Kim, Jeong-Yoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586308/
https://www.ncbi.nlm.nih.gov/pubmed/26329457
http://dx.doi.org/10.7554/eLife.09709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586308/
https://www.ncbi.nlm.nih.gov/pubmed/26329457
http://dx.doi.org/10.7554/eLife.09709

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