Cargando…

Clinical Application of Multigene Panels: Challenges of Next-Generation Counseling and Cancer Risk Management

BACKGROUND: Multigene panels can be a cost- and time-effective alternative to sequentially testing multiple genes, especially with a mixed family cancer phenotype. However, moving beyond our single-gene testing paradigm has unveiled many new challenges to the clinician. The purpose of this article i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Slavin, Thomas Paul, Niell-Swiller, Mariana, Solomon, Ilana, Nehoray, Bita, Rybak, Christina, Blazer, Kathleen R., Weitzel, Jeffrey N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586434/ https://www.ncbi.nlm.nih.gov/pubmed/26484312 http://dx.doi.org/10.3389/fonc.2015.00208

Ejemplares similares

Corrigendum: Clinical Application of Multigene Panels: Challenges of Next-Generation Counseling and Cancer Risk Management
por: Slavin, Thomas Paul, et al.
Publicado: (2015)

Somatic TP53 variants frequently confound germline testing results
por: Weitzel, Jeffrey N., et al.
Publicado: (2017)

Multigene panel next generation sequencing in metastatic colorectal cancer in an Australian population
por: Nindra, Udit, et al.
Publicado: (2023)

Loss-of-function variants in CTNNA1 detected on multigene panel testing in individuals with gastric or breast cancer
por: Clark, Dana Farengo, et al.
Publicado: (2020)

Molecular profiling of male breast cancer by multigene panel testing: Implications for precision oncology
por: Valentini, Virginia, et al.
Publicado: (2023)

Molecular Typing of Lung Adenocarcinoma on Cytological Samples Using a Multigene Next Generation Sequencing Panel
por: Scarpa, Aldo, et al.
Publicado: (2013)

Integration of multigene panels for the diagnosis of hereditary retinal disorders using Next Generation Sequencing and bioinformatics approaches
por: Di Resta, Chiara, et al.
Publicado: (2018)

Clinical Multigene Panel Sequencing Identifies Distinct Mutational Association Patterns in Metastatic Colorectal Cancer
por: Belardinilli, Francesca, et al.
Publicado: (2020)

Molecular characterization of serous ovarian carcinoma using a multigene next generation sequencing cancer panel approach
por: Ab Mutalib, Nurul-Syakima, et al.
Publicado: (2014)

Exploration of intermediate-sized INDELs by next-generation multigene panel testing in Han Chinese patients with breast cancer
por: Hata, Chihiro, et al.
Publicado: (2019)

Molecular Characterization of Pancreatic Ductal Adenocarcinoma Using a Next-Generation Sequencing Custom-Designed Multigene Panel
por: Malvi, Deborah, et al.
Publicado: (2022)

Investigation of germline variants in Bahraini women with breast cancer using next-generation sequencing based-multigene panel
por: Al-Kafaji, Ghada, et al.
Publicado: (2023)

Identification of Lynch Syndrome in Patients with Endometrial Cancer Based on a Germline Next Generation Sequencing Multigene Panel Test
por: Kim, Yoo-Na, et al.
Publicado: (2022)

Identification of Genomic Alterations in Thai Patients With Colorectal Cancer Using Next-Generation Sequencing-Based Multigene Cancer Panel
por: Jinda, Worapoj, et al.
Publicado: (2023)

Implementation of multigene panel testing for breast and ovarian cancer in South Africa: A step towards excellence in oncology for the public sector
por: van der Merwe, Nerina C., et al.
Publicado: (2022)

Investigating the prevalence of pathogenic variants in Saudi Arabian patients with familial cancer using a multigene next generation sequencing panel
por: AlHarbi, Musa, et al.
Publicado: (2023)

Clinical experience with multigene carrier panels in the reproductive setting
por: Terhaar, Catherine, et al.
Publicado: (2018)

Anchored Multiplex PCR Custom Melanoma Next Generation Sequencing Panel for Analysis of Circulating Tumor DNA
por: Diefenbach, Russell J., et al.
Publicado: (2022)

Design and experimental validation of OPERA_MET-A panel for deep methylation analysis by next generation sequencing
por: Fabrizio, Federico Pio, et al.
Publicado: (2022)

Harmonization of Next-Generation Sequencing Procedure in Italian Laboratories: A Multi-Institutional Evaluation of the SiRe® Panel
por: Malapelle, Umberto, et al.
Publicado: (2020)

Multigene Panel Testing for Hereditary Cancer Risk
por: Grissom, Alyssa A., et al.
Publicado: (2016)

Molecular Diagnosis of Neurofibromatosis by Multigene Panel Testing
por: Zhang, Zeng-Yun-Ou, et al.
Publicado: (2021)

Molecular classification grade 3 endometrial endometrioid carcinoma using a next-generation sequencing–based gene panel
por: Li, Ling, et al.
Publicado: (2022)

Implication and Influence of Multigene Panel Testing with Genetic Counseling in Korean Patients with BRCA1/2 Mutation–Negative Breast Cancer
por: Park, Ji Soo, et al.
Publicado: (2022)

Diagnostic Accuracy of Next Generation Sequencing Panel using Circulating Tumor DNA in Patients with Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis
por: Sebastião, Mariana M., et al.
Publicado: (2020)

Molecular Identification and Genetic Characterization of Early-Stage Multiple Primary Lung Cancer by Large-Panel Next-Generation Sequencing Analysis
por: Pei, Guotian, et al.
Publicado: (2021)

Multigene panel predicting survival of patients with colon cancer
por: Li, Hao-Dong, et al.
Publicado: (2019)

Application of Multigene Panels Testing for Hereditary Cancer Syndromes
por: Bilyalov, Airat, et al.
Publicado: (2022)

Germline multigene panel testing of patients with endometrial cancer
por: Kral, Jan, et al.
Publicado: (2023)

Integrated multigene expression panel to prognosticate patients with gastric cancer
por: Kanda, Mitsuro, et al.
Publicado: (2018)

The Benefit of Multigene Panel Testing for the Diagnosis and Management of the Genetic Epilepsies
por: Leduc-Pessah, Heather, et al.
Publicado: (2022)

Multigene Panel Testing in Turkish Hereditary Cancer Syndrome Patients
por: ARSLAN ATES, Esra, et al.
Publicado: (2022)

Should a Multigene Signature be Used in all Luminal Early Breast Cancers
por: Hajjaji, Nawale, et al.
Publicado: (2019)

Melanoma Immunotherapy: Next-Generation Biomarkers
por: Hogan, Sabrina A., et al.
Publicado: (2018)

Principles of Genetic Counseling in the Era of Next-Generation Sequencing
por: Yang, Mina, et al.
Publicado: (2018)

Multigene Panel Germline Testing of 1333 Czech Patients with Ovarian Cancer
por: Lhotova, Klara, et al.
Publicado: (2020)

Genomics of Acute Myeloid Leukemia: The Next Generation
por: Riva, Laura, et al.
Publicado: (2012)

Next-Generation Sequencing of Disseminated Tumor Cells
por: Møller, Elen K., et al.
Publicado: (2013)

Next-Generation in vivo Modeling of Human Cancers
por: Gargiulo, Gaetano
Publicado: (2018)

Nanobodies: Next Generation of Cancer Diagnostics and Therapeutics
por: Yang, Emily Y., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_o72pq3jm1edaqe6fn50ga480rs