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The supramolecular chemistry of lipid oxidation and antioxidation in bulk oils
The microenvironment formed by surface active compounds is being recognized as the active site of lipid oxidation. Trace amounts of water occupy the core of micro micelles and several amphiphilic minor components (e.g., phospholipids, monoacylglycerols, free fatty acids, etc.) act as surfactants and...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586479/ https://www.ncbi.nlm.nih.gov/pubmed/26448722 http://dx.doi.org/10.1002/ejlt.201400200 |
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author | Budilarto, Elizabeth S Kamal-Eldin, Afaf |
author_facet | Budilarto, Elizabeth S Kamal-Eldin, Afaf |
author_sort | Budilarto, Elizabeth S |
collection | PubMed |
description | The microenvironment formed by surface active compounds is being recognized as the active site of lipid oxidation. Trace amounts of water occupy the core of micro micelles and several amphiphilic minor components (e.g., phospholipids, monoacylglycerols, free fatty acids, etc.) act as surfactants and affect lipid oxidation in a complex fashion dependent on the structure and stability of the microemulsions in a continuous lipid phase such as bulk oil. The structures of the triacylglycerols and other lipid-soluble molecules affect their organization and play important roles during the course of the oxidation reactions. Antioxidant head groups, variably located near the water-oil colloidal interfaces, trap and scavenge radicals according to their location and concentration. According to this scenario, antioxidants inhibit lipid oxidation not only by scavenging radicals via hydrogen donation but also by physically stabilizing the micelles at the microenvironments of the reaction sites. There is a cut-off effect (optimum value) governing the inhibitory effects of antioxidants depending inter alias on their hydrophilic/lipophilic balance and their concentrations. These complex effects, previously considered as paradoxes in antioxidants research, are now better explained by the supramolecular chemistry of lipid oxidation and antioxidants, which is discussed in this review. |
format | Online Article Text |
id | pubmed-4586479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-45864792015-10-05 The supramolecular chemistry of lipid oxidation and antioxidation in bulk oils Budilarto, Elizabeth S Kamal-Eldin, Afaf Eur J Lipid Sci Technol Review Article The microenvironment formed by surface active compounds is being recognized as the active site of lipid oxidation. Trace amounts of water occupy the core of micro micelles and several amphiphilic minor components (e.g., phospholipids, monoacylglycerols, free fatty acids, etc.) act as surfactants and affect lipid oxidation in a complex fashion dependent on the structure and stability of the microemulsions in a continuous lipid phase such as bulk oil. The structures of the triacylglycerols and other lipid-soluble molecules affect their organization and play important roles during the course of the oxidation reactions. Antioxidant head groups, variably located near the water-oil colloidal interfaces, trap and scavenge radicals according to their location and concentration. According to this scenario, antioxidants inhibit lipid oxidation not only by scavenging radicals via hydrogen donation but also by physically stabilizing the micelles at the microenvironments of the reaction sites. There is a cut-off effect (optimum value) governing the inhibitory effects of antioxidants depending inter alias on their hydrophilic/lipophilic balance and their concentrations. These complex effects, previously considered as paradoxes in antioxidants research, are now better explained by the supramolecular chemistry of lipid oxidation and antioxidants, which is discussed in this review. John Wiley & Sons, Ltd 2015-08 2015-02-26 /pmc/articles/PMC4586479/ /pubmed/26448722 http://dx.doi.org/10.1002/ejlt.201400200 Text en © 2015 The Authors. European Journal of Lipid Science and Technology Published by Wiley-VCH Verlag GmbH & Co. KGaA http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Article Budilarto, Elizabeth S Kamal-Eldin, Afaf The supramolecular chemistry of lipid oxidation and antioxidation in bulk oils |
title | The supramolecular chemistry of lipid oxidation and antioxidation in bulk oils |
title_full | The supramolecular chemistry of lipid oxidation and antioxidation in bulk oils |
title_fullStr | The supramolecular chemistry of lipid oxidation and antioxidation in bulk oils |
title_full_unstemmed | The supramolecular chemistry of lipid oxidation and antioxidation in bulk oils |
title_short | The supramolecular chemistry of lipid oxidation and antioxidation in bulk oils |
title_sort | supramolecular chemistry of lipid oxidation and antioxidation in bulk oils |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586479/ https://www.ncbi.nlm.nih.gov/pubmed/26448722 http://dx.doi.org/10.1002/ejlt.201400200 |
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