Inhibition of the Rho/Rho kinase pathway prevents lipopolysaccharide-induced hyperalgesia and the release of TNF-α and IL-1β in the mouse spinal cord

Administration of lipopolysaccharide (LPS) by various routes produces profound inflammatory pain hypersensitivity. However, the molecular events that induce this response remain largely uncharacterized. In the present study, we sought to elucidate the role of the Rho/Rho kinase (ROCK) pathway in the...

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Detalles Bibliográficos
Autores principales: Wang, Cunjin, Song, Siyuan, Zhang, Yang, Ge, Yali, Fang, Xiangzhi, Huang, Tianfeng, Du, Jin, Gao, Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586490/
https://www.ncbi.nlm.nih.gov/pubmed/26416580
http://dx.doi.org/10.1038/srep14553

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