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Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism

Per-Arnt-Sim Kinase (PASK) is an evolutionarily-conserved nutrient-responsive protein kinase that regulates lipid and glucose metabolism, mitochondrial respiration, phosphorylation, and gene expression. Recent data suggests that mammalian PAS kinase is involved in glucose metabolism and acts on panc...

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Autores principales: Zhang, Dan-dan, Zhang, Ji-gang, Wang, Yu-zhu, Liu, Ying, Liu, Gao-lin, Li, Xiao-yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586542/
https://www.ncbi.nlm.nih.gov/pubmed/26371032
http://dx.doi.org/10.3390/nu7095347
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author Zhang, Dan-dan
Zhang, Ji-gang
Wang, Yu-zhu
Liu, Ying
Liu, Gao-lin
Li, Xiao-yu
author_facet Zhang, Dan-dan
Zhang, Ji-gang
Wang, Yu-zhu
Liu, Ying
Liu, Gao-lin
Li, Xiao-yu
author_sort Zhang, Dan-dan
collection PubMed
description Per-Arnt-Sim Kinase (PASK) is an evolutionarily-conserved nutrient-responsive protein kinase that regulates lipid and glucose metabolism, mitochondrial respiration, phosphorylation, and gene expression. Recent data suggests that mammalian PAS kinase is involved in glucose metabolism and acts on pancreatic islet α/β cells and glycogen synthase (GS), affecting insulin secretion and blood glucose levels. In addition, PASK knockout mice (PASK-/-) are protected from obesity, liver triglyceride accumulation, and insulin resistance when fed a high-fat diet, implying that PASK may be a new target for metabolic syndrome (MetS) treatment as well as the cellular nutrients and energy sensors—adenosine monophosphate (AMP)-activated protein kinase (AMPK) and the targets of rapamycin (m-TOR). In this review, we will briefly summarize the regulation of PASK on mammalian glucose and lipid metabolism and its possible mechanism, and further explore the potential targets for MetS therapy.
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spelling pubmed-45865422015-10-06 Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism Zhang, Dan-dan Zhang, Ji-gang Wang, Yu-zhu Liu, Ying Liu, Gao-lin Li, Xiao-yu Nutrients Review Per-Arnt-Sim Kinase (PASK) is an evolutionarily-conserved nutrient-responsive protein kinase that regulates lipid and glucose metabolism, mitochondrial respiration, phosphorylation, and gene expression. Recent data suggests that mammalian PAS kinase is involved in glucose metabolism and acts on pancreatic islet α/β cells and glycogen synthase (GS), affecting insulin secretion and blood glucose levels. In addition, PASK knockout mice (PASK-/-) are protected from obesity, liver triglyceride accumulation, and insulin resistance when fed a high-fat diet, implying that PASK may be a new target for metabolic syndrome (MetS) treatment as well as the cellular nutrients and energy sensors—adenosine monophosphate (AMP)-activated protein kinase (AMPK) and the targets of rapamycin (m-TOR). In this review, we will briefly summarize the regulation of PASK on mammalian glucose and lipid metabolism and its possible mechanism, and further explore the potential targets for MetS therapy. MDPI 2015-09-07 /pmc/articles/PMC4586542/ /pubmed/26371032 http://dx.doi.org/10.3390/nu7095347 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Dan-dan
Zhang, Ji-gang
Wang, Yu-zhu
Liu, Ying
Liu, Gao-lin
Li, Xiao-yu
Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism
title Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism
title_full Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism
title_fullStr Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism
title_full_unstemmed Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism
title_short Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism
title_sort per-arnt-sim kinase (pask): an emerging regulator of mammalian glucose and lipid metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586542/
https://www.ncbi.nlm.nih.gov/pubmed/26371032
http://dx.doi.org/10.3390/nu7095347
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