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A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation

Driving human pluripotent stem cells (hPSCs) into specific lineages is an inefficient and challenging process. We show that a potent Src inhibitor, PP1, regulates expression of genes involved in the G1 to S phase transition of the cell cycle, activates proteins in the retinoblastoma family, and subs...

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Detalles Bibliográficos
Autores principales:	Chetty, Sundari, Engquist, Elise N., Mehanna, Elie, Lui, Kathy O., Tsankov, Alexander M., Melton, Douglas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586752/ https://www.ncbi.nlm.nih.gov/pubmed/26416968 http://dx.doi.org/10.1083/jcb.201502035

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