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Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions
Lung cancer is the leading cancer cause of death in the United States. Radiotherapy is an essential component of the definitive treatment of early-stage and locally-advanced lung cancer, and the palliative treatment of metastatic lung cancer. Proton beam therapy (PBT), through its characteristic Bra...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586764/ https://www.ncbi.nlm.nih.gov/pubmed/26147335 http://dx.doi.org/10.3390/cancers7030831 |
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author | Berman, Abigail T. St. James, Sara Rengan, Ramesh |
author_facet | Berman, Abigail T. St. James, Sara Rengan, Ramesh |
author_sort | Berman, Abigail T. |
collection | PubMed |
description | Lung cancer is the leading cancer cause of death in the United States. Radiotherapy is an essential component of the definitive treatment of early-stage and locally-advanced lung cancer, and the palliative treatment of metastatic lung cancer. Proton beam therapy (PBT), through its characteristic Bragg peak, has the potential to decrease the toxicity of radiotherapy, and, subsequently improve the therapeutic ratio. Herein, we provide a primer on the physics of proton beam therapy for lung cancer, present the existing data in early-stage and locally-advanced non-small cell lung cancer (NSCLC), as well as in special situations such as re-irradiation and post-operative radiation therapy. We then present the technical challenges, such as anatomic changes and motion management, and future directions for PBT in lung cancer, including pencil beam scanning. |
format | Online Article Text |
id | pubmed-4586764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45867642015-10-06 Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions Berman, Abigail T. St. James, Sara Rengan, Ramesh Cancers (Basel) Review Lung cancer is the leading cancer cause of death in the United States. Radiotherapy is an essential component of the definitive treatment of early-stage and locally-advanced lung cancer, and the palliative treatment of metastatic lung cancer. Proton beam therapy (PBT), through its characteristic Bragg peak, has the potential to decrease the toxicity of radiotherapy, and, subsequently improve the therapeutic ratio. Herein, we provide a primer on the physics of proton beam therapy for lung cancer, present the existing data in early-stage and locally-advanced non-small cell lung cancer (NSCLC), as well as in special situations such as re-irradiation and post-operative radiation therapy. We then present the technical challenges, such as anatomic changes and motion management, and future directions for PBT in lung cancer, including pencil beam scanning. MDPI 2015-07-02 /pmc/articles/PMC4586764/ /pubmed/26147335 http://dx.doi.org/10.3390/cancers7030831 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Berman, Abigail T. St. James, Sara Rengan, Ramesh Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions |
title | Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions |
title_full | Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions |
title_fullStr | Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions |
title_full_unstemmed | Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions |
title_short | Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions |
title_sort | proton beam therapy for non-small cell lung cancer: current clinical evidence and future directions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586764/ https://www.ncbi.nlm.nih.gov/pubmed/26147335 http://dx.doi.org/10.3390/cancers7030831 |
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