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Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling
The signaling outputs of Receptor Tyrosine Kinases, G-protein coupled receptors and integrins converge to mediate key cell process such as cell adhesion, cell migration, cell invasion and cell proliferation. Once activated by their ligands, these cell surface proteins recruit and direct a diverse ra...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586769/ https://www.ncbi.nlm.nih.gov/pubmed/26184315 http://dx.doi.org/10.3390/cancers7030836 |
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author | Dowling, Catríona M. Kiely, Patrick A. |
author_facet | Dowling, Catríona M. Kiely, Patrick A. |
author_sort | Dowling, Catríona M. |
collection | PubMed |
description | The signaling outputs of Receptor Tyrosine Kinases, G-protein coupled receptors and integrins converge to mediate key cell process such as cell adhesion, cell migration, cell invasion and cell proliferation. Once activated by their ligands, these cell surface proteins recruit and direct a diverse range of proteins to disseminate the appropriate response downstream of the specific environmental cues. One of the key groups of proteins required to regulate these activities is the family of serine/threonine intracellular kinases called Protein Kinase Cs. The activity and subcellular location of PKCs are mediated by a series of tightly regulated events and is dependent on several posttranslational modifications and the availability of second messengers. Protein Kinase Cs exhibit both pro- and anti-tumorigenic effects making them an interesting target for anti-cancer treatment. |
format | Online Article Text |
id | pubmed-4586769 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45867692015-10-06 Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling Dowling, Catríona M. Kiely, Patrick A. Cancers (Basel) Review The signaling outputs of Receptor Tyrosine Kinases, G-protein coupled receptors and integrins converge to mediate key cell process such as cell adhesion, cell migration, cell invasion and cell proliferation. Once activated by their ligands, these cell surface proteins recruit and direct a diverse range of proteins to disseminate the appropriate response downstream of the specific environmental cues. One of the key groups of proteins required to regulate these activities is the family of serine/threonine intracellular kinases called Protein Kinase Cs. The activity and subcellular location of PKCs are mediated by a series of tightly regulated events and is dependent on several posttranslational modifications and the availability of second messengers. Protein Kinase Cs exhibit both pro- and anti-tumorigenic effects making them an interesting target for anti-cancer treatment. MDPI 2015-07-15 /pmc/articles/PMC4586769/ /pubmed/26184315 http://dx.doi.org/10.3390/cancers7030836 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dowling, Catríona M. Kiely, Patrick A. Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling |
title | Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling |
title_full | Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling |
title_fullStr | Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling |
title_full_unstemmed | Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling |
title_short | Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling |
title_sort | targeting protein kinase c downstream of growth factor and adhesion signalling |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586769/ https://www.ncbi.nlm.nih.gov/pubmed/26184315 http://dx.doi.org/10.3390/cancers7030836 |
work_keys_str_mv | AT dowlingcatrionam targetingproteinkinasecdownstreamofgrowthfactorandadhesionsignalling AT kielypatricka targetingproteinkinasecdownstreamofgrowthfactorandadhesionsignalling |