Cargando…

Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling

The signaling outputs of Receptor Tyrosine Kinases, G-protein coupled receptors and integrins converge to mediate key cell process such as cell adhesion, cell migration, cell invasion and cell proliferation. Once activated by their ligands, these cell surface proteins recruit and direct a diverse ra...

Descripción completa

Detalles Bibliográficos
Autores principales: Dowling, Catríona M., Kiely, Patrick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586769/
https://www.ncbi.nlm.nih.gov/pubmed/26184315
http://dx.doi.org/10.3390/cancers7030836
_version_ 1782392429525073920
author Dowling, Catríona M.
Kiely, Patrick A.
author_facet Dowling, Catríona M.
Kiely, Patrick A.
author_sort Dowling, Catríona M.
collection PubMed
description The signaling outputs of Receptor Tyrosine Kinases, G-protein coupled receptors and integrins converge to mediate key cell process such as cell adhesion, cell migration, cell invasion and cell proliferation. Once activated by their ligands, these cell surface proteins recruit and direct a diverse range of proteins to disseminate the appropriate response downstream of the specific environmental cues. One of the key groups of proteins required to regulate these activities is the family of serine/threonine intracellular kinases called Protein Kinase Cs. The activity and subcellular location of PKCs are mediated by a series of tightly regulated events and is dependent on several posttranslational modifications and the availability of second messengers. Protein Kinase Cs exhibit both pro- and anti-tumorigenic effects making them an interesting target for anti-cancer treatment.
format Online
Article
Text
id pubmed-4586769
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-45867692015-10-06 Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling Dowling, Catríona M. Kiely, Patrick A. Cancers (Basel) Review The signaling outputs of Receptor Tyrosine Kinases, G-protein coupled receptors and integrins converge to mediate key cell process such as cell adhesion, cell migration, cell invasion and cell proliferation. Once activated by their ligands, these cell surface proteins recruit and direct a diverse range of proteins to disseminate the appropriate response downstream of the specific environmental cues. One of the key groups of proteins required to regulate these activities is the family of serine/threonine intracellular kinases called Protein Kinase Cs. The activity and subcellular location of PKCs are mediated by a series of tightly regulated events and is dependent on several posttranslational modifications and the availability of second messengers. Protein Kinase Cs exhibit both pro- and anti-tumorigenic effects making them an interesting target for anti-cancer treatment. MDPI 2015-07-15 /pmc/articles/PMC4586769/ /pubmed/26184315 http://dx.doi.org/10.3390/cancers7030836 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dowling, Catríona M.
Kiely, Patrick A.
Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling
title Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling
title_full Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling
title_fullStr Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling
title_full_unstemmed Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling
title_short Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling
title_sort targeting protein kinase c downstream of growth factor and adhesion signalling
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586769/
https://www.ncbi.nlm.nih.gov/pubmed/26184315
http://dx.doi.org/10.3390/cancers7030836
work_keys_str_mv AT dowlingcatrionam targetingproteinkinasecdownstreamofgrowthfactorandadhesionsignalling
AT kielypatricka targetingproteinkinasecdownstreamofgrowthfactorandadhesionsignalling