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Neural Regulation of Pancreatic Cancer: A Novel Target for Intervention
The tumor microenvironment is known to play a pivotal role in driving cancer progression and governing response to therapy. This is of significance in pancreatic cancer where the unique pancreatic tumor microenvironment, characterized by its pronounced desmoplasia and fibrosis, drives early stages o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586771/ https://www.ncbi.nlm.nih.gov/pubmed/26193320 http://dx.doi.org/10.3390/cancers7030838 |
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author | Chang, Aeson Kim-Fuchs, Corina Le, Caroline P. Hollande, Frédéric Sloan, Erica K. |
author_facet | Chang, Aeson Kim-Fuchs, Corina Le, Caroline P. Hollande, Frédéric Sloan, Erica K. |
author_sort | Chang, Aeson |
collection | PubMed |
description | The tumor microenvironment is known to play a pivotal role in driving cancer progression and governing response to therapy. This is of significance in pancreatic cancer where the unique pancreatic tumor microenvironment, characterized by its pronounced desmoplasia and fibrosis, drives early stages of tumor progression and dissemination, and contributes to its associated low survival rates. Several molecular factors that regulate interactions between pancreatic tumors and their surrounding stroma are beginning to be identified. Yet broader physiological factors that influence these interactions remain unclear. Here, we discuss a series of preclinical and mechanistic studies that highlight the important role chronic stress plays as a physiological regulator of neural-tumor interactions in driving the progression of pancreatic cancer. These studies propose several approaches to target stress signaling via the β-adrenergic signaling pathway in order to slow pancreatic tumor growth and metastasis. They also provide evidence to support the use of β-blockers as a novel therapeutic intervention to complement current clinical strategies to improve cancer outcome in patients with pancreatic cancer. |
format | Online Article Text |
id | pubmed-4586771 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45867712015-10-06 Neural Regulation of Pancreatic Cancer: A Novel Target for Intervention Chang, Aeson Kim-Fuchs, Corina Le, Caroline P. Hollande, Frédéric Sloan, Erica K. Cancers (Basel) Review The tumor microenvironment is known to play a pivotal role in driving cancer progression and governing response to therapy. This is of significance in pancreatic cancer where the unique pancreatic tumor microenvironment, characterized by its pronounced desmoplasia and fibrosis, drives early stages of tumor progression and dissemination, and contributes to its associated low survival rates. Several molecular factors that regulate interactions between pancreatic tumors and their surrounding stroma are beginning to be identified. Yet broader physiological factors that influence these interactions remain unclear. Here, we discuss a series of preclinical and mechanistic studies that highlight the important role chronic stress plays as a physiological regulator of neural-tumor interactions in driving the progression of pancreatic cancer. These studies propose several approaches to target stress signaling via the β-adrenergic signaling pathway in order to slow pancreatic tumor growth and metastasis. They also provide evidence to support the use of β-blockers as a novel therapeutic intervention to complement current clinical strategies to improve cancer outcome in patients with pancreatic cancer. MDPI 2015-07-17 /pmc/articles/PMC4586771/ /pubmed/26193320 http://dx.doi.org/10.3390/cancers7030838 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chang, Aeson Kim-Fuchs, Corina Le, Caroline P. Hollande, Frédéric Sloan, Erica K. Neural Regulation of Pancreatic Cancer: A Novel Target for Intervention |
title | Neural Regulation of Pancreatic Cancer: A Novel Target for Intervention |
title_full | Neural Regulation of Pancreatic Cancer: A Novel Target for Intervention |
title_fullStr | Neural Regulation of Pancreatic Cancer: A Novel Target for Intervention |
title_full_unstemmed | Neural Regulation of Pancreatic Cancer: A Novel Target for Intervention |
title_short | Neural Regulation of Pancreatic Cancer: A Novel Target for Intervention |
title_sort | neural regulation of pancreatic cancer: a novel target for intervention |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586771/ https://www.ncbi.nlm.nih.gov/pubmed/26193320 http://dx.doi.org/10.3390/cancers7030838 |
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