Cargando…

The Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human Cancer

Defined cellular mechanisms have evolved that recognize and repair DNA to protect the integrity of its structure and sequence when encountering assaults from endogenous and exogenous sources. There are five major DNA repair pathways: mismatch repair, nucleotide excision repair, direct repair, base e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meng, Erhong, Hanna, Ann, Samant, Rajeev S., Shevde, Lalita A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586772/ https://www.ncbi.nlm.nih.gov/pubmed/26197339 http://dx.doi.org/10.3390/cancers7030839

Ejemplares similares

Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer
por: Meng, Erhong, et al.
Publicado: (2016)

Retraction: Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer
por: Meng, Erhong, et al.
Publicado: (2023)

The Hedgehog Pathway Conditions the Bone Microenvironment for Osteolytic Metastasis of Breast Cancer
por: Das, Shamik, et al.
Publicado: (2012)

Hedgehog signaling enables repair of ribosomal DNA double-strand breaks
por: Lama-Sherpa, Tshering D, et al.
Publicado: (2020)

Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment
por: Hanna, Ann, et al.
Publicado: (2016)

Hedgehog Signaling in Tumor Cells Facilitates Osteoblast-Enhanced Osteolytic Metastases
por: Das, Shamik, et al.
Publicado: (2012)

Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer
por: Hanna, Ann, et al.
Publicado: (2018)

Erratum to: ‘Hedgehog signaling: modulation of cancer properties and tumor microenvironment’
por: Hanna, Ann, et al.
Publicado: (2016)

INCREASED VASCULARITY AND SPONTANEOUS METASTASIS OF BREAST CANCER BY HEDGEHOG SIGNALING MEDIATED UPREGULATION OF CYR61
por: Harris, Lillianne G., et al.
Publicado: (2011)

Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling
por: Das, Shamik, et al.
Publicado: (2017)

Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy
por: Metge, Brandon J., et al.
Publicado: (2023)

Recent Advances in Anti-Angiogenic Therapy of Cancer
por: Samant, Rajeev S., et al.
Publicado: (2011)

NMI and EMT
por: Samant, Rajeev S., et al.
Publicado: (2014)

Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancer
por: Morrow, K. Adam, et al.
Publicado: (2016)

O-GlcNAcylation of GLI Transcription Factors in Hyperglycemic Conditions Augments Hedgehog activity: Hyperglycemic conditions upregulate GLI activity
por: Das, Shamik, et al.
Publicado: (2018)

ALDH1A1 Maintains Ovarian Cancer Stem Cell-Like Properties by Altered Regulation of Cell Cycle Checkpoint and DNA Repair Network Signaling
por: Meng, Erhong, et al.
Publicado: (2014)

The Influence of the Cancer Microenvironment on the Process of Metastasis
por: Frost, Andra R., et al.
Publicado: (2012)

N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cells
por: Metge, Brandon J., et al.
Publicado: (2015)

Micro-RNA-632 down regulates DNAJB6 in breast cancer
por: Mitra, Aparna, et al.
Publicado: (2012)

Hypoxia re-programs 2′-O-Me modifications on ribosomal RNA
por: Metge, Brandon J., et al.
Publicado: (2020)

Ribosome Biogenesis: A Central Player in Cancer Metastasis and Therapeutic Resistance
por: Elhamamsy, Amr R., et al.
Publicado: (2022)

GLI1 upregulates C-JUN through a specific 130-kDa isoform
por: AMABLE, LAUREN, et al.
Publicado: (2013)

Functional characterization of the progestagen-associated endometrial protein gene in human melanoma
por: Ren, Suping, et al.
Publicado: (2010)

Disruption of STAT5A and NMI signaling axis leads to ISG20-driven metastatic mammary tumors
por: Alsheikh, Heba Allah M., et al.
Publicado: (2021)

Spheroid-forming subpopulation of breast cancer cells demonstrates vasculogenic mimicry via hsa-miR-299–5p regulated de novo expression of osteopontin
por: Shevde, Lalita A, et al.
Publicado: (2010)

Merlin regulates signaling events at the nexus of development and cancer
por: Mota, Mateus, et al.
Publicado: (2020)

Merlin deficiency alters the redox management program in breast cancer
por: Mota, Mateus, et al.
Publicado: (2021)

Autocrine/paracrine actions of growth hormone in human melanoma cell lines
por: Buckels, Ashiya, et al.
Publicado: (2019)

Loss of N-Myc interactor promotes epithelial-mesenchymal-transition by activation of TGF-β/SMAD signaling
por: Devine, Daniel J., et al.
Publicado: (2013)

Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors
por: Pruitt, Hawley C., et al.
Publicado: (2018)

Sulindac inhibits tumor cell invasion by suppressing NF-κB mediated transcription of microRNAs
por: Li, Xiaobo, et al.
Publicado: (2012)

Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy
por: Wu, Chuanqing, et al.
Publicado: (2017)

Large isoform of MRJ (DNAJB6) reduces malignant activity of breast cancer
por: Mitra, Aparna, et al.
Publicado: (2008)

Novel role of the dietary flavonoid fisetin in suppressing rRNA biogenesis
por: Kammerud, Sarah C., et al.
Publicado: (2021)

Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activation
por: Samant, Rajeev S, et al.
Publicado: (2007)

Developmental and Repairing Production of Myelin: The Role of Hedgehog Signaling
por: Laouarem, Yousra, et al.
Publicado: (2018)

The Hedgehog signalling pathway in bone formation
por: Yang, Jing, et al.
Publicado: (2015)

Drugging Hedgehog: signaling the pathway to translation
por: Carney, Tom J, et al.
Publicado: (2013)

Hedgehog Signaling Pathway in Ovarian Cancer
por: Szkandera, Joanna, et al.
Publicado: (2013)

The Hedgehog signalling pathway regulates autophagy
por: Jimenez-Sanchez, Maria, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_8a4e91fsf2i111jqu830airre5