Acute Lymphoblastic Leukemia in a Man Treated With Fingolimod for Relapsing Multiple Sclerosis

A man with relapsing multiple sclerosis, treated with fingolimod 0.5 mg/d for 15 months, developed acute lymphoblastic leukemia and died 4 months after immune ablation and bone marrow allograft, from graft versus host disease. To our knowledge, this is the first case of acute lymphoblastic leukemia...

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Detalles Bibliográficos
Autores principales: Cohan, Stanley, Godwin, John, Gaedeke, Leah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586908/
https://www.ncbi.nlm.nih.gov/pubmed/26425635
http://dx.doi.org/10.1177/2324709615575551
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author Cohan, Stanley
Godwin, John
Gaedeke, Leah
author_facet Cohan, Stanley
Godwin, John
Gaedeke, Leah
author_sort Cohan, Stanley
collection PubMed
description A man with relapsing multiple sclerosis, treated with fingolimod 0.5 mg/d for 15 months, developed acute lymphoblastic leukemia and died 4 months after immune ablation and bone marrow allograft, from graft versus host disease. To our knowledge, this is the first case of acute lymphoblastic leukemia reported in a patient treated with fingolimod. Although no causal relationship can be established between fingolimod use and acute lymphoblastic leukemia risk in this single case, future surveillance for lymphatic cell malignancies in patients treated with fingolimod appears justified.
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spelling pubmed-45869082015-09-30 Acute Lymphoblastic Leukemia in a Man Treated With Fingolimod for Relapsing Multiple Sclerosis Cohan, Stanley Godwin, John Gaedeke, Leah J Investig Med High Impact Case Rep Article A man with relapsing multiple sclerosis, treated with fingolimod 0.5 mg/d for 15 months, developed acute lymphoblastic leukemia and died 4 months after immune ablation and bone marrow allograft, from graft versus host disease. To our knowledge, this is the first case of acute lymphoblastic leukemia reported in a patient treated with fingolimod. Although no causal relationship can be established between fingolimod use and acute lymphoblastic leukemia risk in this single case, future surveillance for lymphatic cell malignancies in patients treated with fingolimod appears justified. SAGE Publications 2015-03-09 /pmc/articles/PMC4586908/ /pubmed/26425635 http://dx.doi.org/10.1177/2324709615575551 Text en © 2015 American Federation for Medical Research http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).
spellingShingle Article
Cohan, Stanley
Godwin, John
Gaedeke, Leah
Acute Lymphoblastic Leukemia in a Man Treated With Fingolimod for Relapsing Multiple Sclerosis
title Acute Lymphoblastic Leukemia in a Man Treated With Fingolimod for Relapsing Multiple Sclerosis
title_full Acute Lymphoblastic Leukemia in a Man Treated With Fingolimod for Relapsing Multiple Sclerosis
title_fullStr Acute Lymphoblastic Leukemia in a Man Treated With Fingolimod for Relapsing Multiple Sclerosis
title_full_unstemmed Acute Lymphoblastic Leukemia in a Man Treated With Fingolimod for Relapsing Multiple Sclerosis
title_short Acute Lymphoblastic Leukemia in a Man Treated With Fingolimod for Relapsing Multiple Sclerosis
title_sort acute lymphoblastic leukemia in a man treated with fingolimod for relapsing multiple sclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586908/
https://www.ncbi.nlm.nih.gov/pubmed/26425635
http://dx.doi.org/10.1177/2324709615575551
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AT godwinjohn acutelymphoblasticleukemiainamantreatedwithfingolimodforrelapsingmultiplesclerosis
AT gaedekeleah acutelymphoblasticleukemiainamantreatedwithfingolimodforrelapsingmultiplesclerosis

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