Cargando…
Effects of Probiotics on Biomarkers of Oxidative Stress and Inflammatory Factors in Petrochemical Workers: A Randomized, Double-blind, Placebo-controlled Trial
BACKGROUND: The aim of the current study was to determine effects of probiotic yoghurt and multispecies probiotic capsule supplementation on biomarkers of oxidative stress and inflammatory factors in petrochemical workers. METHODS: This randomized, double-blind, placebo-controlled trial was done amo...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587074/ https://www.ncbi.nlm.nih.gov/pubmed/26445629 http://dx.doi.org/10.4103/2008-7802.164146 |
_version_ | 1782392467856818176 |
---|---|
author | Mohammadi, Ali Akbar Jazayeri, Shima Khosravi-Darani, Kianoush Solati, Zahra Mohammadpour, Nakisa Asemi, Zatollah Adab, Zohre Djalali, Mahmoud Tehrani-Doost, Mehdi Hosseini, Mostafa Eghtesadi, Shahryar |
author_facet | Mohammadi, Ali Akbar Jazayeri, Shima Khosravi-Darani, Kianoush Solati, Zahra Mohammadpour, Nakisa Asemi, Zatollah Adab, Zohre Djalali, Mahmoud Tehrani-Doost, Mehdi Hosseini, Mostafa Eghtesadi, Shahryar |
author_sort | Mohammadi, Ali Akbar |
collection | PubMed |
description | BACKGROUND: The aim of the current study was to determine effects of probiotic yoghurt and multispecies probiotic capsule supplementation on biomarkers of oxidative stress and inflammatory factors in petrochemical workers. METHODS: This randomized, double-blind, placebo-controlled trial was done among petrochemical workers. Subjects were randomly divided into three groups to receive 100 g/day probiotic yogurt (n = 12) or one probiotic capsule daily (n = 13) or 100 g/day conventional yogurt (n = 10) for 6 weeks. The probiotic yoghurt was containing two strains of Lactobacillus acidophilus and Bifidobacterium lactis with a total of min 1 × 10(7) CFU. Multispecies probiotic capsule contains seven probiotic bacteria spices Actobacillus casei 3 × 10(3), L. acidophilus 3 × 10(7), Lactobacillus rhamnosus 7 × 10(9), Lactobacillus bulgaricus 5 × 10(8), Bifidobacterium breve 2 × 10(10), Bifidobacterium longum 1 × 10(9) and Streptococcus thermophilus 3 × 10(8) CFU/g. Fasting blood samples were obtained at the beginning and end of the trial to quantify biomarkers of oxidative stress and inflammatory factors. RESULTS: Although a significant within-group decrease in plasma protein carbonyl levels was seen in the probiotic capsule group (326.0 ± 308.9 vs. 251.0 ± 176.3 ng/mL, P = 0.02), the changes were similar among the three groups. In addition, significant within-group decreases in plasma iso prostaglandin were observed in the probiotic supplements group (111.9 ± 85.4 vs. 88.0 ± 71.0 pg/mL, P = 0.003) and in the probiotic yogurt group (116.3 ± 93.0 vs. 92.0 ± 66.0 pg/mL, P = 0.02), nevertheless there were no significant change among the three groups. CONCLUSIONS: Taken together, consumption of probiotic yogurt or multispecies probiotic capsule had beneficial effects on biomarkers of oxidative stress in petrochemical workers. |
format | Online Article Text |
id | pubmed-4587074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-45870742015-10-06 Effects of Probiotics on Biomarkers of Oxidative Stress and Inflammatory Factors in Petrochemical Workers: A Randomized, Double-blind, Placebo-controlled Trial Mohammadi, Ali Akbar Jazayeri, Shima Khosravi-Darani, Kianoush Solati, Zahra Mohammadpour, Nakisa Asemi, Zatollah Adab, Zohre Djalali, Mahmoud Tehrani-Doost, Mehdi Hosseini, Mostafa Eghtesadi, Shahryar Int J Prev Med Original Article BACKGROUND: The aim of the current study was to determine effects of probiotic yoghurt and multispecies probiotic capsule supplementation on biomarkers of oxidative stress and inflammatory factors in petrochemical workers. METHODS: This randomized, double-blind, placebo-controlled trial was done among petrochemical workers. Subjects were randomly divided into three groups to receive 100 g/day probiotic yogurt (n = 12) or one probiotic capsule daily (n = 13) or 100 g/day conventional yogurt (n = 10) for 6 weeks. The probiotic yoghurt was containing two strains of Lactobacillus acidophilus and Bifidobacterium lactis with a total of min 1 × 10(7) CFU. Multispecies probiotic capsule contains seven probiotic bacteria spices Actobacillus casei 3 × 10(3), L. acidophilus 3 × 10(7), Lactobacillus rhamnosus 7 × 10(9), Lactobacillus bulgaricus 5 × 10(8), Bifidobacterium breve 2 × 10(10), Bifidobacterium longum 1 × 10(9) and Streptococcus thermophilus 3 × 10(8) CFU/g. Fasting blood samples were obtained at the beginning and end of the trial to quantify biomarkers of oxidative stress and inflammatory factors. RESULTS: Although a significant within-group decrease in plasma protein carbonyl levels was seen in the probiotic capsule group (326.0 ± 308.9 vs. 251.0 ± 176.3 ng/mL, P = 0.02), the changes were similar among the three groups. In addition, significant within-group decreases in plasma iso prostaglandin were observed in the probiotic supplements group (111.9 ± 85.4 vs. 88.0 ± 71.0 pg/mL, P = 0.003) and in the probiotic yogurt group (116.3 ± 93.0 vs. 92.0 ± 66.0 pg/mL, P = 0.02), nevertheless there were no significant change among the three groups. CONCLUSIONS: Taken together, consumption of probiotic yogurt or multispecies probiotic capsule had beneficial effects on biomarkers of oxidative stress in petrochemical workers. Medknow Publications & Media Pvt Ltd 2015-09-01 /pmc/articles/PMC4587074/ /pubmed/26445629 http://dx.doi.org/10.4103/2008-7802.164146 Text en Copyright: © 2015 Mohammadi AA. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Original Article Mohammadi, Ali Akbar Jazayeri, Shima Khosravi-Darani, Kianoush Solati, Zahra Mohammadpour, Nakisa Asemi, Zatollah Adab, Zohre Djalali, Mahmoud Tehrani-Doost, Mehdi Hosseini, Mostafa Eghtesadi, Shahryar Effects of Probiotics on Biomarkers of Oxidative Stress and Inflammatory Factors in Petrochemical Workers: A Randomized, Double-blind, Placebo-controlled Trial |
title | Effects of Probiotics on Biomarkers of Oxidative Stress and Inflammatory Factors in Petrochemical Workers: A Randomized, Double-blind, Placebo-controlled Trial |
title_full | Effects of Probiotics on Biomarkers of Oxidative Stress and Inflammatory Factors in Petrochemical Workers: A Randomized, Double-blind, Placebo-controlled Trial |
title_fullStr | Effects of Probiotics on Biomarkers of Oxidative Stress and Inflammatory Factors in Petrochemical Workers: A Randomized, Double-blind, Placebo-controlled Trial |
title_full_unstemmed | Effects of Probiotics on Biomarkers of Oxidative Stress and Inflammatory Factors in Petrochemical Workers: A Randomized, Double-blind, Placebo-controlled Trial |
title_short | Effects of Probiotics on Biomarkers of Oxidative Stress and Inflammatory Factors in Petrochemical Workers: A Randomized, Double-blind, Placebo-controlled Trial |
title_sort | effects of probiotics on biomarkers of oxidative stress and inflammatory factors in petrochemical workers: a randomized, double-blind, placebo-controlled trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587074/ https://www.ncbi.nlm.nih.gov/pubmed/26445629 http://dx.doi.org/10.4103/2008-7802.164146 |
work_keys_str_mv | AT mohammadialiakbar effectsofprobioticsonbiomarkersofoxidativestressandinflammatoryfactorsinpetrochemicalworkersarandomizeddoubleblindplacebocontrolledtrial AT jazayerishima effectsofprobioticsonbiomarkersofoxidativestressandinflammatoryfactorsinpetrochemicalworkersarandomizeddoubleblindplacebocontrolledtrial AT khosravidaranikianoush effectsofprobioticsonbiomarkersofoxidativestressandinflammatoryfactorsinpetrochemicalworkersarandomizeddoubleblindplacebocontrolledtrial AT solatizahra effectsofprobioticsonbiomarkersofoxidativestressandinflammatoryfactorsinpetrochemicalworkersarandomizeddoubleblindplacebocontrolledtrial AT mohammadpournakisa effectsofprobioticsonbiomarkersofoxidativestressandinflammatoryfactorsinpetrochemicalworkersarandomizeddoubleblindplacebocontrolledtrial AT asemizatollah effectsofprobioticsonbiomarkersofoxidativestressandinflammatoryfactorsinpetrochemicalworkersarandomizeddoubleblindplacebocontrolledtrial AT adabzohre effectsofprobioticsonbiomarkersofoxidativestressandinflammatoryfactorsinpetrochemicalworkersarandomizeddoubleblindplacebocontrolledtrial AT djalalimahmoud effectsofprobioticsonbiomarkersofoxidativestressandinflammatoryfactorsinpetrochemicalworkersarandomizeddoubleblindplacebocontrolledtrial AT tehranidoostmehdi effectsofprobioticsonbiomarkersofoxidativestressandinflammatoryfactorsinpetrochemicalworkersarandomizeddoubleblindplacebocontrolledtrial AT hosseinimostafa effectsofprobioticsonbiomarkersofoxidativestressandinflammatoryfactorsinpetrochemicalworkersarandomizeddoubleblindplacebocontrolledtrial AT eghtesadishahryar effectsofprobioticsonbiomarkersofoxidativestressandinflammatoryfactorsinpetrochemicalworkersarandomizeddoubleblindplacebocontrolledtrial |