A Rare Case of Melanosis of the Hard Palate Mucosa in a Patient with Chronic Myeloid Leukemia

Imatinib Mesylate, also known as Gleevec or ST1-571, is a tyrosine-kinase inhibitor used as the gold standard medication for the chronic myeloid leukemia (CML); Imatinib has indeed deeply revolutionized the CML therapy allowing most patients to have a good quality of life. Despite its beneficial eff...

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Autores principales: Romeo, Umberto, Palaia, Gaspare, Fantozzi, Paolo Junior, Tenore, Gianluca, Bosco, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587433/
https://www.ncbi.nlm.nih.gov/pubmed/26451262
http://dx.doi.org/10.1155/2015/817094
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author Romeo, Umberto
Palaia, Gaspare
Fantozzi, Paolo Junior
Tenore, Gianluca
Bosco, Daniela
author_facet Romeo, Umberto
Palaia, Gaspare
Fantozzi, Paolo Junior
Tenore, Gianluca
Bosco, Daniela
author_sort Romeo, Umberto
collection PubMed
description Imatinib Mesylate, also known as Gleevec or ST1-571, is a tyrosine-kinase inhibitor used as the gold standard medication for the chronic myeloid leukemia (CML); Imatinib has indeed deeply revolutionized the CML therapy allowing most patients to have a good quality of life. Despite its beneficial effects, Imatinib has significant side effects such as mucosal pigmentation. A 72-year-old female having an Imatinib induced mucosal pigmentation is presented: she has been treated with Imatinib since 2003 and only in 2014 discovered, during a routine dental visit, having a pigmented lesion on her hard palate mucosa. Histopathologically, the lesion shows the deposition of fine dark brown spherical bodies within the lamina propria and cloaked in between the collagen fibers. There was no sign of inflammation, hyperplasia, or hemorrhage in the tissue.
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spelling pubmed-45874332015-10-08 A Rare Case of Melanosis of the Hard Palate Mucosa in a Patient with Chronic Myeloid Leukemia Romeo, Umberto Palaia, Gaspare Fantozzi, Paolo Junior Tenore, Gianluca Bosco, Daniela Case Rep Dent Case Report Imatinib Mesylate, also known as Gleevec or ST1-571, is a tyrosine-kinase inhibitor used as the gold standard medication for the chronic myeloid leukemia (CML); Imatinib has indeed deeply revolutionized the CML therapy allowing most patients to have a good quality of life. Despite its beneficial effects, Imatinib has significant side effects such as mucosal pigmentation. A 72-year-old female having an Imatinib induced mucosal pigmentation is presented: she has been treated with Imatinib since 2003 and only in 2014 discovered, during a routine dental visit, having a pigmented lesion on her hard palate mucosa. Histopathologically, the lesion shows the deposition of fine dark brown spherical bodies within the lamina propria and cloaked in between the collagen fibers. There was no sign of inflammation, hyperplasia, or hemorrhage in the tissue. Hindawi Publishing Corporation 2015 2015-09-15 /pmc/articles/PMC4587433/ /pubmed/26451262 http://dx.doi.org/10.1155/2015/817094 Text en Copyright © 2015 Umberto Romeo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Romeo, Umberto
Palaia, Gaspare
Fantozzi, Paolo Junior
Tenore, Gianluca
Bosco, Daniela
A Rare Case of Melanosis of the Hard Palate Mucosa in a Patient with Chronic Myeloid Leukemia
title A Rare Case of Melanosis of the Hard Palate Mucosa in a Patient with Chronic Myeloid Leukemia
title_full A Rare Case of Melanosis of the Hard Palate Mucosa in a Patient with Chronic Myeloid Leukemia
title_fullStr A Rare Case of Melanosis of the Hard Palate Mucosa in a Patient with Chronic Myeloid Leukemia
title_full_unstemmed A Rare Case of Melanosis of the Hard Palate Mucosa in a Patient with Chronic Myeloid Leukemia
title_short A Rare Case of Melanosis of the Hard Palate Mucosa in a Patient with Chronic Myeloid Leukemia
title_sort rare case of melanosis of the hard palate mucosa in a patient with chronic myeloid leukemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587433/
https://www.ncbi.nlm.nih.gov/pubmed/26451262
http://dx.doi.org/10.1155/2015/817094
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