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Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound

There is no cure for osteoarthritis. Current drug delivery relies on systemic delivery or injections into the joint. Because articular cartilage (AC) degeneration can be local and drug exposure outside the lesion can cause adverse effects, localized drug delivery could permit new drug treatment stra...

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Autores principales: Nieminen, Heikki J., Ylitalo, Tuomo, Suuronen, Jussi-Petteri, Rahunen, Krista, Salmi, Ari, Saarakkala, Simo, Serimaa, Ritva, Hæggström, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587538/
https://www.ncbi.nlm.nih.gov/pubmed/25922135
http://dx.doi.org/10.1016/j.ultrasmedbio.2015.03.025
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author Nieminen, Heikki J.
Ylitalo, Tuomo
Suuronen, Jussi-Petteri
Rahunen, Krista
Salmi, Ari
Saarakkala, Simo
Serimaa, Ritva
Hæggström, Edward
author_facet Nieminen, Heikki J.
Ylitalo, Tuomo
Suuronen, Jussi-Petteri
Rahunen, Krista
Salmi, Ari
Saarakkala, Simo
Serimaa, Ritva
Hæggström, Edward
author_sort Nieminen, Heikki J.
collection PubMed
description There is no cure for osteoarthritis. Current drug delivery relies on systemic delivery or injections into the joint. Because articular cartilage (AC) degeneration can be local and drug exposure outside the lesion can cause adverse effects, localized drug delivery could permit new drug treatment strategies. We investigated whether intense megahertz ultrasound (frequency: 1.138 MHz, peak positive pressure: 2.7 MPa, I(spta): 5 W/cm(2), beam width: 5.7 mm at −6 dB, duty cycle: 5%, pulse repetition frequency: 285 Hz, mechanical index: 1.1) can deliver agents into AC without damaging it. Using ultrasound, we delivered a drug surrogate down to a depth corresponding to 53% depth of the AC thickness without causing histologically detectable damage to the AC. This may be important because early osteoarthritis typically exhibits histopathologic changes in the superficial AC. In conclusion, we identify intense megahertz ultrasound as a technique that potentially enables localized non-destructive delivery of osteoarthritis drugs or drug carriers into articular cartilage.
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spelling pubmed-45875382015-09-29 Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound Nieminen, Heikki J. Ylitalo, Tuomo Suuronen, Jussi-Petteri Rahunen, Krista Salmi, Ari Saarakkala, Simo Serimaa, Ritva Hæggström, Edward Ultrasound Med Biol Technical Note There is no cure for osteoarthritis. Current drug delivery relies on systemic delivery or injections into the joint. Because articular cartilage (AC) degeneration can be local and drug exposure outside the lesion can cause adverse effects, localized drug delivery could permit new drug treatment strategies. We investigated whether intense megahertz ultrasound (frequency: 1.138 MHz, peak positive pressure: 2.7 MPa, I(spta): 5 W/cm(2), beam width: 5.7 mm at −6 dB, duty cycle: 5%, pulse repetition frequency: 285 Hz, mechanical index: 1.1) can deliver agents into AC without damaging it. Using ultrasound, we delivered a drug surrogate down to a depth corresponding to 53% depth of the AC thickness without causing histologically detectable damage to the AC. This may be important because early osteoarthritis typically exhibits histopathologic changes in the superficial AC. In conclusion, we identify intense megahertz ultrasound as a technique that potentially enables localized non-destructive delivery of osteoarthritis drugs or drug carriers into articular cartilage. Pergamon Press 2015-08 /pmc/articles/PMC4587538/ /pubmed/25922135 http://dx.doi.org/10.1016/j.ultrasmedbio.2015.03.025 Text en © 2015 World Federation for Ultrasound in Medicine & Biology. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Technical Note
Nieminen, Heikki J.
Ylitalo, Tuomo
Suuronen, Jussi-Petteri
Rahunen, Krista
Salmi, Ari
Saarakkala, Simo
Serimaa, Ritva
Hæggström, Edward
Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound
title Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound
title_full Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound
title_fullStr Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound
title_full_unstemmed Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound
title_short Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound
title_sort delivering agents locally into articular cartilage by intense mhz ultrasound
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587538/
https://www.ncbi.nlm.nih.gov/pubmed/25922135
http://dx.doi.org/10.1016/j.ultrasmedbio.2015.03.025
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