The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein

BACKGROUND: Since the identification of poly-alanine expanded poly(A) binding protein nuclear 1 (PABPN1) as the genetic cause of oculopharyngeal muscular dystrophy (OPMD), considerable progress has been made in our understanding of the pathogenesis of the disease. However, the molecular mechanisms t...

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Detalles Bibliográficos
Autores principales: Shi, Chao, Huang, Xuan, Zhang, Bin, Zhu, Dan, Luo, Huqiao, Lu, Quqin, Xiong, Wen-Cheng, Mei, Lin, Luo, Shiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587574/
https://www.ncbi.nlm.nih.gov/pubmed/26414348
http://dx.doi.org/10.1371/journal.pone.0138936

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