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Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice
OBJECTIVE: Tabernaemontana divaricata (TD) from Apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. The aim of the present study was to evaluate the effect of ethanolic extract of TD leaves on burying behavior in...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mashhad University of Medical Sciences
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587605/ https://www.ncbi.nlm.nih.gov/pubmed/26445709 |
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author | Chanchal, Raj Balasubramaniam, Arumugam Navin, Raj Nadeem, Sayyed |
author_facet | Chanchal, Raj Balasubramaniam, Arumugam Navin, Raj Nadeem, Sayyed |
author_sort | Chanchal, Raj |
collection | PubMed |
description | OBJECTIVE: Tabernaemontana divaricata (TD) from Apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. The aim of the present study was to evaluate the effect of ethanolic extract of TD leaves on burying behavior in mice. MATERIALS AND METHODS: Mice were treated with oral administration (p.o.) of ethanolic extract of TD (100, 200, and 300 mg/kg). Fluoxetine (FLX, a selective serotonin reuptake inhibitor) was used as a reference drug. Obsessive-compulsive behavior was evaluated using marble-burying apparatus. RESULTS: TD at doses of 100, 200, and 300 mg/kg dose-dependently inhibited the obsessive and compulsive behavior. The similar results were obtained from 5, 10, and 20 mg/kg of FLX. TD and FLX did not affect motor activity. CONCLUSION: The results indicated that TD and FLX produced similar inhibitory effects on marble-burying behavior. |
format | Online Article Text |
id | pubmed-4587605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Mashhad University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-45876052015-10-06 Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice Chanchal, Raj Balasubramaniam, Arumugam Navin, Raj Nadeem, Sayyed Avicenna J Phytomed Short Communication OBJECTIVE: Tabernaemontana divaricata (TD) from Apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. The aim of the present study was to evaluate the effect of ethanolic extract of TD leaves on burying behavior in mice. MATERIALS AND METHODS: Mice were treated with oral administration (p.o.) of ethanolic extract of TD (100, 200, and 300 mg/kg). Fluoxetine (FLX, a selective serotonin reuptake inhibitor) was used as a reference drug. Obsessive-compulsive behavior was evaluated using marble-burying apparatus. RESULTS: TD at doses of 100, 200, and 300 mg/kg dose-dependently inhibited the obsessive and compulsive behavior. The similar results were obtained from 5, 10, and 20 mg/kg of FLX. TD and FLX did not affect motor activity. CONCLUSION: The results indicated that TD and FLX produced similar inhibitory effects on marble-burying behavior. Mashhad University of Medical Sciences 2015 /pmc/articles/PMC4587605/ /pubmed/26445709 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Chanchal, Raj Balasubramaniam, Arumugam Navin, Raj Nadeem, Sayyed Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice |
title |
Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice |
title_full |
Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice |
title_fullStr |
Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice |
title_full_unstemmed |
Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice |
title_short |
Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice |
title_sort | tabernaemontana divaricata leaves extract exacerbate burying behavior in mice |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587605/ https://www.ncbi.nlm.nih.gov/pubmed/26445709 |
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