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Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice

OBJECTIVE: Tabernaemontana divaricata (TD) from Apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. The aim of the present study was to evaluate the effect of ethanolic extract of TD leaves on burying behavior in...

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Autores principales: Chanchal, Raj, Balasubramaniam, Arumugam, Navin, Raj, Nadeem, Sayyed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587605/
https://www.ncbi.nlm.nih.gov/pubmed/26445709
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author Chanchal, Raj
Balasubramaniam, Arumugam
Navin, Raj
Nadeem, Sayyed
author_facet Chanchal, Raj
Balasubramaniam, Arumugam
Navin, Raj
Nadeem, Sayyed
author_sort Chanchal, Raj
collection PubMed
description OBJECTIVE: Tabernaemontana divaricata (TD) from Apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. The aim of the present study was to evaluate the effect of ethanolic extract of TD leaves on burying behavior in mice. MATERIALS AND METHODS: Mice were treated with oral administration (p.o.) of ethanolic extract of TD (100, 200, and 300 mg/kg). Fluoxetine (FLX, a selective serotonin reuptake inhibitor) was used as a reference drug. Obsessive-compulsive behavior was evaluated using marble-burying apparatus. RESULTS: TD at doses of 100, 200, and 300 mg/kg dose-dependently inhibited the obsessive and compulsive behavior. The similar results were obtained from 5, 10, and 20 mg/kg of FLX. TD and FLX did not affect motor activity. CONCLUSION: The results indicated that TD and FLX produced similar inhibitory effects on marble-burying behavior.
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spelling pubmed-45876052015-10-06 Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice Chanchal, Raj Balasubramaniam, Arumugam Navin, Raj Nadeem, Sayyed Avicenna J Phytomed Short Communication OBJECTIVE: Tabernaemontana divaricata (TD) from Apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. The aim of the present study was to evaluate the effect of ethanolic extract of TD leaves on burying behavior in mice. MATERIALS AND METHODS: Mice were treated with oral administration (p.o.) of ethanolic extract of TD (100, 200, and 300 mg/kg). Fluoxetine (FLX, a selective serotonin reuptake inhibitor) was used as a reference drug. Obsessive-compulsive behavior was evaluated using marble-burying apparatus. RESULTS: TD at doses of 100, 200, and 300 mg/kg dose-dependently inhibited the obsessive and compulsive behavior. The similar results were obtained from 5, 10, and 20 mg/kg of FLX. TD and FLX did not affect motor activity. CONCLUSION: The results indicated that TD and FLX produced similar inhibitory effects on marble-burying behavior. Mashhad University of Medical Sciences 2015 /pmc/articles/PMC4587605/ /pubmed/26445709 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Chanchal, Raj
Balasubramaniam, Arumugam
Navin, Raj
Nadeem, Sayyed
Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice
title Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice
title_full Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice
title_fullStr Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice
title_full_unstemmed Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice
title_short Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice
title_sort tabernaemontana divaricata leaves extract exacerbate burying behavior in mice
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587605/
https://www.ncbi.nlm.nih.gov/pubmed/26445709
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