Revealing Annexin A2 and ARF-6 enrollment during Trypanosoma cruzi extracellular amastigote-host cell interaction

BACKGROUND: Invasion of host cells by Trypanosoma cruzi extracellular amastigotes is host actin polymerization-dependent. However, the role of proteins related to actin dynamics during invasion by amastigotes remains to be investigated. Here we describe the role of Annexin A2 and ARF-6 during extrac...

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Detalles Bibliográficos
Autores principales: Teixeira, Thaise Lara, Cruz, Lilian, Mortara, Renato Arruda, Da Silva, Claudio Vieira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587755/
https://www.ncbi.nlm.nih.gov/pubmed/26416603
http://dx.doi.org/10.1186/s13071-015-1097-6
Descripción
Sumario:BACKGROUND: Invasion of host cells by Trypanosoma cruzi extracellular amastigotes is host actin polymerization-dependent. However, the role of proteins related to actin dynamics during invasion by amastigotes remains to be investigated. Here we describe the role of Annexin A2 and ARF-6 during extracellular amastigote-mammalian cell interactions. FINDINGS: Our results showed ARF-6 accumulation in the amastigote-containing parasitophorous vacuole containing amastigote forms; demonstrated ARF-6 and Annexin A2 critical impact over parasite cell invasion and revealed the effect of Annexin A2 expression on intracellular parasite multiplication. CONCLUSION: ARF-6 and Annexin A2 are involved in invasion of mammalian cells by T. cruzi amastigotes.

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