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The negative impact of spasticity on the health-related quality of life of stroke survivors: a longitudinal cohort study
BACKGROUND: Spasticity often leads to symptomatic and functional problems that can cause disability for stroke survivors. We studied whether spasticity has a negative impact on health-related quality of life (HRQoL). METHODS: As part of the Greater Cincinnati/Northern Kentucky Stroke Study (NCT00642...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587810/ https://www.ncbi.nlm.nih.gov/pubmed/26415945 http://dx.doi.org/10.1186/s12955-015-0340-3 |
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author | Gillard, Patrick J. Sucharew, Heidi Kleindorfer, Dawn Belagaje, Samir Varon, Sepideh Alwell, Kathleen Moomaw, Charles J. Woo, Daniel Khatri, Pooja Flaherty, Matthew L. Adeoye, Opeolu Ferioli, Simona Kissela, Brett |
author_facet | Gillard, Patrick J. Sucharew, Heidi Kleindorfer, Dawn Belagaje, Samir Varon, Sepideh Alwell, Kathleen Moomaw, Charles J. Woo, Daniel Khatri, Pooja Flaherty, Matthew L. Adeoye, Opeolu Ferioli, Simona Kissela, Brett |
author_sort | Gillard, Patrick J. |
collection | PubMed |
description | BACKGROUND: Spasticity often leads to symptomatic and functional problems that can cause disability for stroke survivors. We studied whether spasticity has a negative impact on health-related quality of life (HRQoL). METHODS: As part of the Greater Cincinnati/Northern Kentucky Stroke Study (NCT00642213), 460 ischemic stroke patients were interviewed during hospitalization and then followed over time. HRQoL was measured by the Physical Component Summary (PCS) and Mental Component Summary (MCS) scores of the Short Form-12 (SF-12), EuroQol-5 dimension (EQ-5D), and Stroke-Specific Quality of Life (SSQOL) instruments, with lower scores indicating worse health. HRQoL differences between stroke survivors with and without spasticity were compared, adjusting for age, race, stroke severity, pre-stroke function, and comorbidities. RESULTS: Of the 460 ischemic stroke patients, 328 had spasticity data available 3 months after their stroke (mean age of 66 years, 49 % were female, and 26 % were black). Of these patients, 54 (16 %) reported having spasticity. Three months following their stroke, patients who reported spasticity had lower mean scores on the PCS (29.6 ± 1.4 vs 37.3 ± 0.6; P < .001), EQ-5D (0.59 ± 0.03 vs 0.71 ± 0.01; P < .001), and SSQOL (3.57 ± 0.08 versus 3.78 ± 0.03; P = .03) compared with patients who did not report spasticity. Lower HRQoL scores were also observed at the 1-year (PCS, EQ-5D, and SSQOL) and 2-year (EQ-5D and SSQOL) interviews in those with spasticity compared with those without spasticity. CONCLUSIONS: Statistically and clinically meaningful differences in HRQoL exist between stroke survivors with and without spasticity. |
format | Online Article Text |
id | pubmed-4587810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45878102015-09-30 The negative impact of spasticity on the health-related quality of life of stroke survivors: a longitudinal cohort study Gillard, Patrick J. Sucharew, Heidi Kleindorfer, Dawn Belagaje, Samir Varon, Sepideh Alwell, Kathleen Moomaw, Charles J. Woo, Daniel Khatri, Pooja Flaherty, Matthew L. Adeoye, Opeolu Ferioli, Simona Kissela, Brett Health Qual Life Outcomes Research BACKGROUND: Spasticity often leads to symptomatic and functional problems that can cause disability for stroke survivors. We studied whether spasticity has a negative impact on health-related quality of life (HRQoL). METHODS: As part of the Greater Cincinnati/Northern Kentucky Stroke Study (NCT00642213), 460 ischemic stroke patients were interviewed during hospitalization and then followed over time. HRQoL was measured by the Physical Component Summary (PCS) and Mental Component Summary (MCS) scores of the Short Form-12 (SF-12), EuroQol-5 dimension (EQ-5D), and Stroke-Specific Quality of Life (SSQOL) instruments, with lower scores indicating worse health. HRQoL differences between stroke survivors with and without spasticity were compared, adjusting for age, race, stroke severity, pre-stroke function, and comorbidities. RESULTS: Of the 460 ischemic stroke patients, 328 had spasticity data available 3 months after their stroke (mean age of 66 years, 49 % were female, and 26 % were black). Of these patients, 54 (16 %) reported having spasticity. Three months following their stroke, patients who reported spasticity had lower mean scores on the PCS (29.6 ± 1.4 vs 37.3 ± 0.6; P < .001), EQ-5D (0.59 ± 0.03 vs 0.71 ± 0.01; P < .001), and SSQOL (3.57 ± 0.08 versus 3.78 ± 0.03; P = .03) compared with patients who did not report spasticity. Lower HRQoL scores were also observed at the 1-year (PCS, EQ-5D, and SSQOL) and 2-year (EQ-5D and SSQOL) interviews in those with spasticity compared with those without spasticity. CONCLUSIONS: Statistically and clinically meaningful differences in HRQoL exist between stroke survivors with and without spasticity. BioMed Central 2015-09-29 /pmc/articles/PMC4587810/ /pubmed/26415945 http://dx.doi.org/10.1186/s12955-015-0340-3 Text en © Gillard et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Gillard, Patrick J. Sucharew, Heidi Kleindorfer, Dawn Belagaje, Samir Varon, Sepideh Alwell, Kathleen Moomaw, Charles J. Woo, Daniel Khatri, Pooja Flaherty, Matthew L. Adeoye, Opeolu Ferioli, Simona Kissela, Brett The negative impact of spasticity on the health-related quality of life of stroke survivors: a longitudinal cohort study |
title | The negative impact of spasticity on the health-related quality of life of stroke survivors: a longitudinal cohort study |
title_full | The negative impact of spasticity on the health-related quality of life of stroke survivors: a longitudinal cohort study |
title_fullStr | The negative impact of spasticity on the health-related quality of life of stroke survivors: a longitudinal cohort study |
title_full_unstemmed | The negative impact of spasticity on the health-related quality of life of stroke survivors: a longitudinal cohort study |
title_short | The negative impact of spasticity on the health-related quality of life of stroke survivors: a longitudinal cohort study |
title_sort | negative impact of spasticity on the health-related quality of life of stroke survivors: a longitudinal cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587810/ https://www.ncbi.nlm.nih.gov/pubmed/26415945 http://dx.doi.org/10.1186/s12955-015-0340-3 |
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