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Early BCG vaccine to low-birth-weight infants and the effects on growth in the first year of life: a randomised controlled trial
BACKGROUND: Randomised trials have shown that early Bacille Calmette-Guérin (BCG) vaccine reduces overall neonatal and infant mortality. However, no study has examined how BCG affects growth. We investigated the effect on infant growth of early BCG vaccine given to low-birth-weight (LBW) infants. ME...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587923/ https://www.ncbi.nlm.nih.gov/pubmed/26416147 http://dx.doi.org/10.1186/s12887-015-0452-2 |
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author | Biering-Sørensen, Sofie Andersen, Andreas Ravn, Henrik Monterio, Ivan Aaby, Peter Benn, Christine Stabell |
author_facet | Biering-Sørensen, Sofie Andersen, Andreas Ravn, Henrik Monterio, Ivan Aaby, Peter Benn, Christine Stabell |
author_sort | Biering-Sørensen, Sofie |
collection | PubMed |
description | BACKGROUND: Randomised trials have shown that early Bacille Calmette-Guérin (BCG) vaccine reduces overall neonatal and infant mortality. However, no study has examined how BCG affects growth. We investigated the effect on infant growth of early BCG vaccine given to low-birth-weight (LBW) infants. METHODS: Two-thousand three hundred forty-three LBW infants were randomly allocated 1:1 to “early BCG” (intervention group) or “late BCG” (current practice). Furthermore, a subgroup (N = 1717) were included in a two-by-two randomised trial in which they were additionally randomised 1:1 to vitamin A supplementation (VAS) or placebo. Anthropometric measurements were obtained 2, 6, and 12 months after enrolment. RESULTS: Overall there was no effect of early BCG on growth in the first year of life. The effect of early BCG on weight and mid-upper-arm circumference at 2 months tended to be beneficial among girls but not among boys (interaction between “early BCG” and sex: weight p = 0.03 and MUAC p = 0.04). This beneficial effect among girls was particularly seen among the largest infants weighing 2.0 kg or more at inclusion. CONCLUSION: Though BCG vaccination is not recommended to be given to LBW infants at birth in Guinea-Bissau, early BCG had no negative effect on infant growth and may have had a beneficial effect for girls. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov (NCT00146302). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12887-015-0452-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4587923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45879232015-09-30 Early BCG vaccine to low-birth-weight infants and the effects on growth in the first year of life: a randomised controlled trial Biering-Sørensen, Sofie Andersen, Andreas Ravn, Henrik Monterio, Ivan Aaby, Peter Benn, Christine Stabell BMC Pediatr Research Article BACKGROUND: Randomised trials have shown that early Bacille Calmette-Guérin (BCG) vaccine reduces overall neonatal and infant mortality. However, no study has examined how BCG affects growth. We investigated the effect on infant growth of early BCG vaccine given to low-birth-weight (LBW) infants. METHODS: Two-thousand three hundred forty-three LBW infants were randomly allocated 1:1 to “early BCG” (intervention group) or “late BCG” (current practice). Furthermore, a subgroup (N = 1717) were included in a two-by-two randomised trial in which they were additionally randomised 1:1 to vitamin A supplementation (VAS) or placebo. Anthropometric measurements were obtained 2, 6, and 12 months after enrolment. RESULTS: Overall there was no effect of early BCG on growth in the first year of life. The effect of early BCG on weight and mid-upper-arm circumference at 2 months tended to be beneficial among girls but not among boys (interaction between “early BCG” and sex: weight p = 0.03 and MUAC p = 0.04). This beneficial effect among girls was particularly seen among the largest infants weighing 2.0 kg or more at inclusion. CONCLUSION: Though BCG vaccination is not recommended to be given to LBW infants at birth in Guinea-Bissau, early BCG had no negative effect on infant growth and may have had a beneficial effect for girls. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov (NCT00146302). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12887-015-0452-2) contains supplementary material, which is available to authorized users. BioMed Central 2015-09-28 /pmc/articles/PMC4587923/ /pubmed/26416147 http://dx.doi.org/10.1186/s12887-015-0452-2 Text en © Biering-Sørensen et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Biering-Sørensen, Sofie Andersen, Andreas Ravn, Henrik Monterio, Ivan Aaby, Peter Benn, Christine Stabell Early BCG vaccine to low-birth-weight infants and the effects on growth in the first year of life: a randomised controlled trial |
title | Early BCG vaccine to low-birth-weight infants and the effects on growth in the first year of life: a randomised controlled trial |
title_full | Early BCG vaccine to low-birth-weight infants and the effects on growth in the first year of life: a randomised controlled trial |
title_fullStr | Early BCG vaccine to low-birth-weight infants and the effects on growth in the first year of life: a randomised controlled trial |
title_full_unstemmed | Early BCG vaccine to low-birth-weight infants and the effects on growth in the first year of life: a randomised controlled trial |
title_short | Early BCG vaccine to low-birth-weight infants and the effects on growth in the first year of life: a randomised controlled trial |
title_sort | early bcg vaccine to low-birth-weight infants and the effects on growth in the first year of life: a randomised controlled trial |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587923/ https://www.ncbi.nlm.nih.gov/pubmed/26416147 http://dx.doi.org/10.1186/s12887-015-0452-2 |
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