Cargando…
Quantitative Analysis of Vortical Blood Flow in the Thoracic Aorta Using 4D Phase Contrast MRI
INTRODUCTION: Phase contrast MRI allows for the examination of complex hemodynamics in the heart and adjacent great vessels. Vortex flow patterns seem to play an important role in certain vascular pathologies. We propose two- and three-dimensional metrics for the objective quantification of aortic v...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587936/ https://www.ncbi.nlm.nih.gov/pubmed/26418327 http://dx.doi.org/10.1371/journal.pone.0139025 |
_version_ | 1782392544451100672 |
---|---|
author | von Spiczak, Jochen Crelier, Gerard Giese, Daniel Kozerke, Sebastian Maintz, David Bunck, Alexander Christian |
author_facet | von Spiczak, Jochen Crelier, Gerard Giese, Daniel Kozerke, Sebastian Maintz, David Bunck, Alexander Christian |
author_sort | von Spiczak, Jochen |
collection | PubMed |
description | INTRODUCTION: Phase contrast MRI allows for the examination of complex hemodynamics in the heart and adjacent great vessels. Vortex flow patterns seem to play an important role in certain vascular pathologies. We propose two- and three-dimensional metrics for the objective quantification of aortic vortex blood flow in 4D phase contrast MRI. MATERIALS AND METHODS: For two-dimensional vorticity assessment, a standardized set of 6 regions-of-interest (ROIs) was defined throughout the course of the aorta. For each ROI, a heatmap of time-resolved vorticity values [Image: see text] was computed. Evolution of minimum, maximum, and average values as well as opposing rotational flow components were analyzed. For three-dimensional analysis, vortex core detection was implemented combining the predictor-corrector method with λ(2) correction. Strength, elongation, and radial expansion of the detected vortex core were recorded over time. All methods were applied to 4D flow MRI datasets of 9 healthy subjects, 2 patients with mildly dilated aorta, and 1 patient with aortic aneurysm. RESULTS: Vorticity quantification in the 6 standardized ROIs enabled the description of physiological vortex flow in the healthy aorta. Helical flow developed early in the ascending aorta (absolute vorticity = 166.4±86.4 s(-1) at 12% of cardiac cycle) followed by maximum values in mid-systole in the aortic arch (240.1±45.2 s(-1) at 16%). Strength, elongation, and radial expansion of 3D vortex cores escalated in early systole, reaching a peak in mid systole (strength = 241.2±30.7 s(-1) at 17%, elongation = 65.1±34.6 mm at 18%, expansion = 80.1±48.8 mm(2) at 20%), before all three parameters similarly decreased to overall low values in diastole. Flow patterns were considerably altered in patient data: Vortex flow developed late in mid/end-systole close to the aortic bulb and no physiological helix was found in the aortic arch. CONCLUSIONS: We have introduced objective measures for quantification of vortical flow in 4D phase contrast MRI. Vortex blood flow in the thoracic aorta could be consistently described in all healthy volunteers. In patient data, pathologically altered vortex flow was observed. |
format | Online Article Text |
id | pubmed-4587936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-45879362015-10-02 Quantitative Analysis of Vortical Blood Flow in the Thoracic Aorta Using 4D Phase Contrast MRI von Spiczak, Jochen Crelier, Gerard Giese, Daniel Kozerke, Sebastian Maintz, David Bunck, Alexander Christian PLoS One Research Article INTRODUCTION: Phase contrast MRI allows for the examination of complex hemodynamics in the heart and adjacent great vessels. Vortex flow patterns seem to play an important role in certain vascular pathologies. We propose two- and three-dimensional metrics for the objective quantification of aortic vortex blood flow in 4D phase contrast MRI. MATERIALS AND METHODS: For two-dimensional vorticity assessment, a standardized set of 6 regions-of-interest (ROIs) was defined throughout the course of the aorta. For each ROI, a heatmap of time-resolved vorticity values [Image: see text] was computed. Evolution of minimum, maximum, and average values as well as opposing rotational flow components were analyzed. For three-dimensional analysis, vortex core detection was implemented combining the predictor-corrector method with λ(2) correction. Strength, elongation, and radial expansion of the detected vortex core were recorded over time. All methods were applied to 4D flow MRI datasets of 9 healthy subjects, 2 patients with mildly dilated aorta, and 1 patient with aortic aneurysm. RESULTS: Vorticity quantification in the 6 standardized ROIs enabled the description of physiological vortex flow in the healthy aorta. Helical flow developed early in the ascending aorta (absolute vorticity = 166.4±86.4 s(-1) at 12% of cardiac cycle) followed by maximum values in mid-systole in the aortic arch (240.1±45.2 s(-1) at 16%). Strength, elongation, and radial expansion of 3D vortex cores escalated in early systole, reaching a peak in mid systole (strength = 241.2±30.7 s(-1) at 17%, elongation = 65.1±34.6 mm at 18%, expansion = 80.1±48.8 mm(2) at 20%), before all three parameters similarly decreased to overall low values in diastole. Flow patterns were considerably altered in patient data: Vortex flow developed late in mid/end-systole close to the aortic bulb and no physiological helix was found in the aortic arch. CONCLUSIONS: We have introduced objective measures for quantification of vortical flow in 4D phase contrast MRI. Vortex blood flow in the thoracic aorta could be consistently described in all healthy volunteers. In patient data, pathologically altered vortex flow was observed. Public Library of Science 2015-09-29 /pmc/articles/PMC4587936/ /pubmed/26418327 http://dx.doi.org/10.1371/journal.pone.0139025 Text en © 2015 von Spiczak et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article von Spiczak, Jochen Crelier, Gerard Giese, Daniel Kozerke, Sebastian Maintz, David Bunck, Alexander Christian Quantitative Analysis of Vortical Blood Flow in the Thoracic Aorta Using 4D Phase Contrast MRI |
title | Quantitative Analysis of Vortical Blood Flow in the Thoracic Aorta Using 4D Phase Contrast MRI |
title_full | Quantitative Analysis of Vortical Blood Flow in the Thoracic Aorta Using 4D Phase Contrast MRI |
title_fullStr | Quantitative Analysis of Vortical Blood Flow in the Thoracic Aorta Using 4D Phase Contrast MRI |
title_full_unstemmed | Quantitative Analysis of Vortical Blood Flow in the Thoracic Aorta Using 4D Phase Contrast MRI |
title_short | Quantitative Analysis of Vortical Blood Flow in the Thoracic Aorta Using 4D Phase Contrast MRI |
title_sort | quantitative analysis of vortical blood flow in the thoracic aorta using 4d phase contrast mri |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587936/ https://www.ncbi.nlm.nih.gov/pubmed/26418327 http://dx.doi.org/10.1371/journal.pone.0139025 |
work_keys_str_mv | AT vonspiczakjochen quantitativeanalysisofvorticalbloodflowinthethoracicaortausing4dphasecontrastmri AT creliergerard quantitativeanalysisofvorticalbloodflowinthethoracicaortausing4dphasecontrastmri AT giesedaniel quantitativeanalysisofvorticalbloodflowinthethoracicaortausing4dphasecontrastmri AT kozerkesebastian quantitativeanalysisofvorticalbloodflowinthethoracicaortausing4dphasecontrastmri AT maintzdavid quantitativeanalysisofvorticalbloodflowinthethoracicaortausing4dphasecontrastmri AT bunckalexanderchristian quantitativeanalysisofvorticalbloodflowinthethoracicaortausing4dphasecontrastmri |