Intranasal Administration of Lentiviral miR-135a Regulates Mast Cell and Allergen-Induced Inflammation by Targeting GATA-3

Mast cell (MC) degranulation is the foundation of the acute phase of allergic rhinitis (AR). Previously, downregulation of GATA binding protein 3 (GATA-3) was shown to suppress MC activation in an AR mouse model. Binding of microRNA-135a (miR-135a) to GATA-3 was also observed, and overexpression of...

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Detalles Bibliográficos
Autores principales: Deng, Yu-Qin, Yang, Ya-Qi, Wang, Shui-Bin, Li, Fen, Liu, Meng-Zhi, Hua, Qing-Quan, Tao, Ze-Zhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587974/
https://www.ncbi.nlm.nih.gov/pubmed/26418311
http://dx.doi.org/10.1371/journal.pone.0139322

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