The Possible Roles of the Dentate Granule Cell’s Leptin and Other Ciliary Receptors in Alzheimer’s Neuropathology

Dentate-gyral granule cells in the hippocampus plus dentate gyrus memory-recording/retrieving machine, unlike most other neurons in the brain, are continuously being generated in the adult brain with the important task of separating overlapping patterns of data streaming in from the outside world vi...

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Autores principales: Whitfield, James F., Chiarini, Anna, Dal Prà, Ilaria, Armato, Ubaldo, Chakravarthy, Balu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588035/
https://www.ncbi.nlm.nih.gov/pubmed/26184316
http://dx.doi.org/10.3390/cells4030253
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author Whitfield, James F.
Chiarini, Anna
Dal Prà, Ilaria
Armato, Ubaldo
Chakravarthy, Balu
author_facet Whitfield, James F.
Chiarini, Anna
Dal Prà, Ilaria
Armato, Ubaldo
Chakravarthy, Balu
author_sort Whitfield, James F.
collection PubMed
description Dentate-gyral granule cells in the hippocampus plus dentate gyrus memory-recording/retrieving machine, unlike most other neurons in the brain, are continuously being generated in the adult brain with the important task of separating overlapping patterns of data streaming in from the outside world via the entorhinal cortex. This “adult neurogenesis” is driven by tools in the mature granule cell’s cilium. Here we report our discovery of leptin’s LepRb receptor in this cilium. In addition, we discuss how ciliary LepRb signaling might be involved with ciliary p75(NTR) and SSTR3 receptors in adult neurogenesis and memory formation as well as attenuation of Alzheimer’s neuropathology by reducing the production of its toxic amyloid-β-derived drivers.
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spelling pubmed-45880352015-10-08 The Possible Roles of the Dentate Granule Cell’s Leptin and Other Ciliary Receptors in Alzheimer’s Neuropathology Whitfield, James F. Chiarini, Anna Dal Prà, Ilaria Armato, Ubaldo Chakravarthy, Balu Cells Review Dentate-gyral granule cells in the hippocampus plus dentate gyrus memory-recording/retrieving machine, unlike most other neurons in the brain, are continuously being generated in the adult brain with the important task of separating overlapping patterns of data streaming in from the outside world via the entorhinal cortex. This “adult neurogenesis” is driven by tools in the mature granule cell’s cilium. Here we report our discovery of leptin’s LepRb receptor in this cilium. In addition, we discuss how ciliary LepRb signaling might be involved with ciliary p75(NTR) and SSTR3 receptors in adult neurogenesis and memory formation as well as attenuation of Alzheimer’s neuropathology by reducing the production of its toxic amyloid-β-derived drivers. MDPI 2015-07-13 /pmc/articles/PMC4588035/ /pubmed/26184316 http://dx.doi.org/10.3390/cells4030253 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Whitfield, James F.
Chiarini, Anna
Dal Prà, Ilaria
Armato, Ubaldo
Chakravarthy, Balu
The Possible Roles of the Dentate Granule Cell’s Leptin and Other Ciliary Receptors in Alzheimer’s Neuropathology
title The Possible Roles of the Dentate Granule Cell’s Leptin and Other Ciliary Receptors in Alzheimer’s Neuropathology
title_full The Possible Roles of the Dentate Granule Cell’s Leptin and Other Ciliary Receptors in Alzheimer’s Neuropathology
title_fullStr The Possible Roles of the Dentate Granule Cell’s Leptin and Other Ciliary Receptors in Alzheimer’s Neuropathology
title_full_unstemmed The Possible Roles of the Dentate Granule Cell’s Leptin and Other Ciliary Receptors in Alzheimer’s Neuropathology
title_short The Possible Roles of the Dentate Granule Cell’s Leptin and Other Ciliary Receptors in Alzheimer’s Neuropathology
title_sort possible roles of the dentate granule cell’s leptin and other ciliary receptors in alzheimer’s neuropathology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588035/
https://www.ncbi.nlm.nih.gov/pubmed/26184316
http://dx.doi.org/10.3390/cells4030253
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