Cyclic GMP and Cilia Motility

Motile cilia of the lungs respond to environmental challenges by increasing their ciliary beat frequency in order to enhance mucociliary clearance as a fundamental tenant of innate defense. One important second messenger in transducing the regulable nature of motile cilia is cyclic guanosine 3′,5′-m...

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Detalles Bibliográficos
Autor principal: Wyatt, Todd A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588039/
https://www.ncbi.nlm.nih.gov/pubmed/26264028
http://dx.doi.org/10.3390/cells4030315
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author Wyatt, Todd A.
author_facet Wyatt, Todd A.
author_sort Wyatt, Todd A.
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description Motile cilia of the lungs respond to environmental challenges by increasing their ciliary beat frequency in order to enhance mucociliary clearance as a fundamental tenant of innate defense. One important second messenger in transducing the regulable nature of motile cilia is cyclic guanosine 3′,5′-monophosphate (cGMP). In this review, the history of cGMP action is presented and a survey of the existing data addressing cGMP action in ciliary motility is presented. Nitric oxide (NO)-mediated regulation of cGMP in ciliated cells is presented in the context of alcohol-induced cilia function and dysfunction.
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spelling pubmed-45880392015-10-08 Cyclic GMP and Cilia Motility Wyatt, Todd A. Cells Review Motile cilia of the lungs respond to environmental challenges by increasing their ciliary beat frequency in order to enhance mucociliary clearance as a fundamental tenant of innate defense. One important second messenger in transducing the regulable nature of motile cilia is cyclic guanosine 3′,5′-monophosphate (cGMP). In this review, the history of cGMP action is presented and a survey of the existing data addressing cGMP action in ciliary motility is presented. Nitric oxide (NO)-mediated regulation of cGMP in ciliated cells is presented in the context of alcohol-induced cilia function and dysfunction. MDPI 2015-07-31 /pmc/articles/PMC4588039/ /pubmed/26264028 http://dx.doi.org/10.3390/cells4030315 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wyatt, Todd A.
Cyclic GMP and Cilia Motility
title Cyclic GMP and Cilia Motility
title_full Cyclic GMP and Cilia Motility
title_fullStr Cyclic GMP and Cilia Motility
title_full_unstemmed Cyclic GMP and Cilia Motility
title_short Cyclic GMP and Cilia Motility
title_sort cyclic gmp and cilia motility
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588039/
https://www.ncbi.nlm.nih.gov/pubmed/26264028
http://dx.doi.org/10.3390/cells4030315
work_keys_str_mv AT wyatttodda cyclicgmpandciliamotility

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